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T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8

HLA-DQ8, a genetic risk factor in type I diabetes (T1D), presents hybrid insulin peptides (HIPs) to autoreactive CD4+ T cells. The abundance of spliced peptides binding to HLA-DQ8 and how they are subsequently recognised by the autoreactive T cell repertoire is unknown. Here we report, the HIP (GQVE...

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Detalles Bibliográficos
Autores principales:	Tran, Mai T., Faridi, Pouya, Lim, Jia Jia, Ting, Yi Tian, Onwukwe, Goodluck, Bhattacharjee, Pushpak, Jones, Claerwen M., Tresoldi, Eleonora, Cameron, Fergus J., La Gruta, Nicole L., Purcell, Anthony W., Mannering, Stuart I., Rossjohn, Jamie, Reid, Hugh H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387461/ https://www.ncbi.nlm.nih.gov/pubmed/34433824 http://dx.doi.org/10.1038/s41467-021-25404-x

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