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Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study

Human milk (HM) is the golden standard of infant nutrition that can protect immature body function and enhance nutrition metabolism to ensure infant growth. Region specificity and lactation period could change the protein composition in HM. In this research, proteomics analysis was used to compare p...

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Autores principales: Sari, Ratna Nurmalita, Pan, Jiancun, Zhang, Wenyuan, Li, Yuanyuan, Zhu, Huiquan, Pang, Xiaoyang, Zhang, Shuwen, Jiang, Shilong, Lu, Jing, Lv, Jiaping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387594/
https://www.ncbi.nlm.nih.gov/pubmed/34458300
http://dx.doi.org/10.3389/fnut.2021.682429
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author Sari, Ratna Nurmalita
Pan, Jiancun
Zhang, Wenyuan
Li, Yuanyuan
Zhu, Huiquan
Pang, Xiaoyang
Zhang, Shuwen
Jiang, Shilong
Lu, Jing
Lv, Jiaping
author_facet Sari, Ratna Nurmalita
Pan, Jiancun
Zhang, Wenyuan
Li, Yuanyuan
Zhu, Huiquan
Pang, Xiaoyang
Zhang, Shuwen
Jiang, Shilong
Lu, Jing
Lv, Jiaping
author_sort Sari, Ratna Nurmalita
collection PubMed
description Human milk (HM) is the golden standard of infant nutrition that can protect immature body function and enhance nutrition metabolism to ensure infant growth. Region specificity and lactation period could change the protein composition in HM. In this research, proteomics analysis was used to compare proteomes across eight cities, namely Harbin, Lanzhou, Guangzhou, Chengdu, Jinhua, Weihai, Zhengzhou, and Beijing, which represented the northeast, northwest, southeast, southwest, east, and north and central regions of China,. Proteins varied significantly among the cities. These different proteins were mainly involved in the process of platelet degranulation, innate immune response, and triglyceride metabolic process, which might be due to different living environments. These differences also lead to variation in protection and fat metabolism from mothers to infants in different cities. Four proteins were expressed differently during 6 months of lactation, namely Dipeptidyl peptidase 1, Lysozyme C, Carbonic anhydrase 6, and Chordin-like protein 2. The changes in these proteins might be because of the change of growth needs of the infants. The findings from our results might help to improve the understanding of HM as well as to design infant formula.
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spelling pubmed-83875942021-08-27 Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study Sari, Ratna Nurmalita Pan, Jiancun Zhang, Wenyuan Li, Yuanyuan Zhu, Huiquan Pang, Xiaoyang Zhang, Shuwen Jiang, Shilong Lu, Jing Lv, Jiaping Front Nutr Nutrition Human milk (HM) is the golden standard of infant nutrition that can protect immature body function and enhance nutrition metabolism to ensure infant growth. Region specificity and lactation period could change the protein composition in HM. In this research, proteomics analysis was used to compare proteomes across eight cities, namely Harbin, Lanzhou, Guangzhou, Chengdu, Jinhua, Weihai, Zhengzhou, and Beijing, which represented the northeast, northwest, southeast, southwest, east, and north and central regions of China,. Proteins varied significantly among the cities. These different proteins were mainly involved in the process of platelet degranulation, innate immune response, and triglyceride metabolic process, which might be due to different living environments. These differences also lead to variation in protection and fat metabolism from mothers to infants in different cities. Four proteins were expressed differently during 6 months of lactation, namely Dipeptidyl peptidase 1, Lysozyme C, Carbonic anhydrase 6, and Chordin-like protein 2. The changes in these proteins might be because of the change of growth needs of the infants. The findings from our results might help to improve the understanding of HM as well as to design infant formula. Frontiers Media S.A. 2021-08-12 /pmc/articles/PMC8387594/ /pubmed/34458300 http://dx.doi.org/10.3389/fnut.2021.682429 Text en Copyright © 2021 Sari, Pan, Zhang, Li, Zhu, Pang, Zhang, Jiang, Lu and Lv. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Sari, Ratna Nurmalita
Pan, Jiancun
Zhang, Wenyuan
Li, Yuanyuan
Zhu, Huiquan
Pang, Xiaoyang
Zhang, Shuwen
Jiang, Shilong
Lu, Jing
Lv, Jiaping
Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study
title Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study
title_full Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study
title_fullStr Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study
title_full_unstemmed Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study
title_short Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study
title_sort comparative proteomics of human milk from eight cities in china during six months of lactation in the chinese human milk project study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387594/
https://www.ncbi.nlm.nih.gov/pubmed/34458300
http://dx.doi.org/10.3389/fnut.2021.682429
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