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Replaceability of Schiff base proton donors in light-driven proton pump rhodopsins

Many H(+)-pump rhodopsins conserve “H(+) donor” residues in cytoplasmic (CP) half channels to quickly transport H(+) from the CP medium to Schiff bases at the center of these proteins. For conventional H(+) pumps, the donors are conserved as Asp or Glu but are replaced by Lys in the minority, such a...

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Detalles Bibliográficos
Autores principales: Sasaki, Syogo, Tamogami, Jun, Nishiya, Koki, Demura, Makoto, Kikukawa, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387761/
https://www.ncbi.nlm.nih.gov/pubmed/34329681
http://dx.doi.org/10.1016/j.jbc.2021.101013