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Time Restricted Eating: A Dietary Strategy to Prevent and Treat Metabolic Disturbances
Time-restricted eating (TRE), a dietary approach limiting the daily eating window, has attracted increasing attention in media and research. The eating behavior in our modern society is often characterized by prolonged and erratic daily eating patterns, which might be associated with increased risk...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387818/ https://www.ncbi.nlm.nih.gov/pubmed/34456861 http://dx.doi.org/10.3389/fendo.2021.683140 |
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author | Schuppelius, Bettina Peters, Beeke Ottawa, Agnieszka Pivovarova-Ramich, Olga |
author_facet | Schuppelius, Bettina Peters, Beeke Ottawa, Agnieszka Pivovarova-Ramich, Olga |
author_sort | Schuppelius, Bettina |
collection | PubMed |
description | Time-restricted eating (TRE), a dietary approach limiting the daily eating window, has attracted increasing attention in media and research. The eating behavior in our modern society is often characterized by prolonged and erratic daily eating patterns, which might be associated with increased risk of obesity, diabetes, and cardiovascular diseases. In contrast, recent evidence suggests that TRE might support weight loss, improve cardiometabolic health, and overall wellbeing, but the data are controversial. The present work reviews how TRE affects glucose and lipid metabolism based on clinical trials published until June 2021. A range of trials demonstrated that TRE intervention lowered fasting and postprandial glucose levels in response to a standard meal or oral glucose tolerance test, as well as mean 24-h glucose and glycemic excursions assessed using continuous glucose monitoring. In addition, fasting insulin decreases and improvement of insulin sensitivity were demonstrated. These changes were often accompanied by the decrease of blood triglyceride and cholesterol levels. However, a number of studies found that TRE had either adverse or no effects on glycemic and lipid traits, which might be explained by the different study designs (i.e., fasting/eating duration, daytime of eating, changes of calorie intake, duration of intervention) and study subject cohorts (metabolic status, age, gender, chronotype, etc.). To summarize, TRE represents an attractive and easy-to-adapt dietary strategy for the prevention and therapy of glucose and lipid metabolic disturbances. However, carefully controlled future TRE studies are needed to confirm these effects to understand the underlying mechanisms and assess the applicability of personalized interventions. |
format | Online Article Text |
id | pubmed-8387818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83878182021-08-27 Time Restricted Eating: A Dietary Strategy to Prevent and Treat Metabolic Disturbances Schuppelius, Bettina Peters, Beeke Ottawa, Agnieszka Pivovarova-Ramich, Olga Front Endocrinol (Lausanne) Endocrinology Time-restricted eating (TRE), a dietary approach limiting the daily eating window, has attracted increasing attention in media and research. The eating behavior in our modern society is often characterized by prolonged and erratic daily eating patterns, which might be associated with increased risk of obesity, diabetes, and cardiovascular diseases. In contrast, recent evidence suggests that TRE might support weight loss, improve cardiometabolic health, and overall wellbeing, but the data are controversial. The present work reviews how TRE affects glucose and lipid metabolism based on clinical trials published until June 2021. A range of trials demonstrated that TRE intervention lowered fasting and postprandial glucose levels in response to a standard meal or oral glucose tolerance test, as well as mean 24-h glucose and glycemic excursions assessed using continuous glucose monitoring. In addition, fasting insulin decreases and improvement of insulin sensitivity were demonstrated. These changes were often accompanied by the decrease of blood triglyceride and cholesterol levels. However, a number of studies found that TRE had either adverse or no effects on glycemic and lipid traits, which might be explained by the different study designs (i.e., fasting/eating duration, daytime of eating, changes of calorie intake, duration of intervention) and study subject cohorts (metabolic status, age, gender, chronotype, etc.). To summarize, TRE represents an attractive and easy-to-adapt dietary strategy for the prevention and therapy of glucose and lipid metabolic disturbances. However, carefully controlled future TRE studies are needed to confirm these effects to understand the underlying mechanisms and assess the applicability of personalized interventions. Frontiers Media S.A. 2021-08-12 /pmc/articles/PMC8387818/ /pubmed/34456861 http://dx.doi.org/10.3389/fendo.2021.683140 Text en Copyright © 2021 Schuppelius, Peters, Ottawa and Pivovarova-Ramich https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Schuppelius, Bettina Peters, Beeke Ottawa, Agnieszka Pivovarova-Ramich, Olga Time Restricted Eating: A Dietary Strategy to Prevent and Treat Metabolic Disturbances |
title | Time Restricted Eating: A Dietary Strategy to Prevent and Treat Metabolic Disturbances |
title_full | Time Restricted Eating: A Dietary Strategy to Prevent and Treat Metabolic Disturbances |
title_fullStr | Time Restricted Eating: A Dietary Strategy to Prevent and Treat Metabolic Disturbances |
title_full_unstemmed | Time Restricted Eating: A Dietary Strategy to Prevent and Treat Metabolic Disturbances |
title_short | Time Restricted Eating: A Dietary Strategy to Prevent and Treat Metabolic Disturbances |
title_sort | time restricted eating: a dietary strategy to prevent and treat metabolic disturbances |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387818/ https://www.ncbi.nlm.nih.gov/pubmed/34456861 http://dx.doi.org/10.3389/fendo.2021.683140 |
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