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Maintenance therapy with subcutaneous immunoglobulin in a patient with immune‐mediated neuropathic postural tachycardia syndrome

AIMS: We describe the disease course of a 35-year-old female with an autoimmune mediated neuropathic postural tachycardia syndrome (PoTS), who responded to immunoglobulin therapy and stabilized on maintenance therapy with subcutaneous immunoglobulin (SCIg). METHODS: We provide longitudinal data of c...

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Autores principales: Pitarokoili, Kalliopi, Maier, Andrea, de Moya Rubio, Elena C., Hahn, Katrin, Wallukat, Gerd, Athanasopoulos, Diamantis, Grüter, Thomas, Motte, Jeremias, Fisse, Anna Lena, Gold, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387908/
https://www.ncbi.nlm.nih.gov/pubmed/34471867
http://dx.doi.org/10.1016/j.jtauto.2021.100112
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author Pitarokoili, Kalliopi
Maier, Andrea
de Moya Rubio, Elena C.
Hahn, Katrin
Wallukat, Gerd
Athanasopoulos, Diamantis
Grüter, Thomas
Motte, Jeremias
Fisse, Anna Lena
Gold, Ralf
author_facet Pitarokoili, Kalliopi
Maier, Andrea
de Moya Rubio, Elena C.
Hahn, Katrin
Wallukat, Gerd
Athanasopoulos, Diamantis
Grüter, Thomas
Motte, Jeremias
Fisse, Anna Lena
Gold, Ralf
author_sort Pitarokoili, Kalliopi
collection PubMed
description AIMS: We describe the disease course of a 35-year-old female with an autoimmune mediated neuropathic postural tachycardia syndrome (PoTS), who responded to immunoglobulin therapy and stabilized on maintenance therapy with subcutaneous immunoglobulin (SCIg). METHODS: We provide longitudinal data of clinical scores, tilt-table results and antibody titers. RESULTS: Initial treatment with intravenous immunoglobulin caused infusion-related side-effects whereas SCIg was well tolerated and improved clinical symptoms and quality of life. Clinical improvement correlated with the reduction of serum antibody titers 22 months after first infusion. CONCLUSIONS: These findings suggest that autoimmune-mediated neuropathic PoTS can be treated sufficiently with IVIg whereas SCIg minimizes side-effects.
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spelling pubmed-83879082021-08-31 Maintenance therapy with subcutaneous immunoglobulin in a patient with immune‐mediated neuropathic postural tachycardia syndrome Pitarokoili, Kalliopi Maier, Andrea de Moya Rubio, Elena C. Hahn, Katrin Wallukat, Gerd Athanasopoulos, Diamantis Grüter, Thomas Motte, Jeremias Fisse, Anna Lena Gold, Ralf J Transl Autoimmun Case report AIMS: We describe the disease course of a 35-year-old female with an autoimmune mediated neuropathic postural tachycardia syndrome (PoTS), who responded to immunoglobulin therapy and stabilized on maintenance therapy with subcutaneous immunoglobulin (SCIg). METHODS: We provide longitudinal data of clinical scores, tilt-table results and antibody titers. RESULTS: Initial treatment with intravenous immunoglobulin caused infusion-related side-effects whereas SCIg was well tolerated and improved clinical symptoms and quality of life. Clinical improvement correlated with the reduction of serum antibody titers 22 months after first infusion. CONCLUSIONS: These findings suggest that autoimmune-mediated neuropathic PoTS can be treated sufficiently with IVIg whereas SCIg minimizes side-effects. Elsevier 2021-08-14 /pmc/articles/PMC8387908/ /pubmed/34471867 http://dx.doi.org/10.1016/j.jtauto.2021.100112 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case report
Pitarokoili, Kalliopi
Maier, Andrea
de Moya Rubio, Elena C.
Hahn, Katrin
Wallukat, Gerd
Athanasopoulos, Diamantis
Grüter, Thomas
Motte, Jeremias
Fisse, Anna Lena
Gold, Ralf
Maintenance therapy with subcutaneous immunoglobulin in a patient with immune‐mediated neuropathic postural tachycardia syndrome
title Maintenance therapy with subcutaneous immunoglobulin in a patient with immune‐mediated neuropathic postural tachycardia syndrome
title_full Maintenance therapy with subcutaneous immunoglobulin in a patient with immune‐mediated neuropathic postural tachycardia syndrome
title_fullStr Maintenance therapy with subcutaneous immunoglobulin in a patient with immune‐mediated neuropathic postural tachycardia syndrome
title_full_unstemmed Maintenance therapy with subcutaneous immunoglobulin in a patient with immune‐mediated neuropathic postural tachycardia syndrome
title_short Maintenance therapy with subcutaneous immunoglobulin in a patient with immune‐mediated neuropathic postural tachycardia syndrome
title_sort maintenance therapy with subcutaneous immunoglobulin in a patient with immune‐mediated neuropathic postural tachycardia syndrome
topic Case report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387908/
https://www.ncbi.nlm.nih.gov/pubmed/34471867
http://dx.doi.org/10.1016/j.jtauto.2021.100112
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