Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

OBJECTIVE: Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In humans, homozygous mutations of NEUROG3 manifest with neonatal or childhood diabetes. Despite this critical role i...

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Detalles Bibliográficos
Autores principales: Schreiber, Valérie, Mercier, Reuben, Jiménez, Sara, Ye, Tao, García-Sánchez, Emmanuel, Klein, Annabelle, Meunier, Aline, Ghimire, Sabitri, Birck, Catherine, Jost, Bernard, de Lichtenberg, Kristian Honnens, Honoré, Christian, Serup, Palle, Gradwohl, Gérard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387919/
https://www.ncbi.nlm.nih.gov/pubmed/34352411
http://dx.doi.org/10.1016/j.molmet.2021.101313

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