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Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation

Stroke is a leading cause of death and disability worldwide. However, our understanding of its underlying biology and the number of available treatment options remain limited. Mendelian randomization (MR) offers a powerful approach to identify novel biological pathways and therapeutic targets for th...

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Autores principales: Acosta, Julián N., Szejko, Natalia, Falcone, Guido J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387928/
https://www.ncbi.nlm.nih.gov/pubmed/34456968
http://dx.doi.org/10.3389/fgene.2021.683082
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author Acosta, Julián N.
Szejko, Natalia
Falcone, Guido J.
author_facet Acosta, Julián N.
Szejko, Natalia
Falcone, Guido J.
author_sort Acosta, Julián N.
collection PubMed
description Stroke is a leading cause of death and disability worldwide. However, our understanding of its underlying biology and the number of available treatment options remain limited. Mendelian randomization (MR) offers a powerful approach to identify novel biological pathways and therapeutic targets for this disease. Around ~100 MR studies have been conducted so far to explore, confirm, and quantify causal relationships between several exposures and risk of stroke. In this review, we summarize the current evidence arising from these studies, including those investigating ischemic stroke, hemorrhagic stroke, or both. We highlight the different types of exposures that are currently under study, ranging from well-known cardiovascular risk factors to less established inflammation-related mechanisms. Finally, we provide an overview of future avenues of research and novel approaches, including drug target validation MR, which is poised to have a substantial impact on drug development and drug repurposing.
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spelling pubmed-83879282021-08-27 Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation Acosta, Julián N. Szejko, Natalia Falcone, Guido J. Front Genet Genetics Stroke is a leading cause of death and disability worldwide. However, our understanding of its underlying biology and the number of available treatment options remain limited. Mendelian randomization (MR) offers a powerful approach to identify novel biological pathways and therapeutic targets for this disease. Around ~100 MR studies have been conducted so far to explore, confirm, and quantify causal relationships between several exposures and risk of stroke. In this review, we summarize the current evidence arising from these studies, including those investigating ischemic stroke, hemorrhagic stroke, or both. We highlight the different types of exposures that are currently under study, ranging from well-known cardiovascular risk factors to less established inflammation-related mechanisms. Finally, we provide an overview of future avenues of research and novel approaches, including drug target validation MR, which is poised to have a substantial impact on drug development and drug repurposing. Frontiers Media S.A. 2021-08-12 /pmc/articles/PMC8387928/ /pubmed/34456968 http://dx.doi.org/10.3389/fgene.2021.683082 Text en Copyright © 2021 Acosta, Szejko and Falcone. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Acosta, Julián N.
Szejko, Natalia
Falcone, Guido J.
Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
title Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
title_full Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
title_fullStr Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
title_full_unstemmed Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
title_short Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
title_sort mendelian randomization in stroke: a powerful approach to causal inference and drug target validation
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387928/
https://www.ncbi.nlm.nih.gov/pubmed/34456968
http://dx.doi.org/10.3389/fgene.2021.683082
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