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Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy
Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387963/ https://www.ncbi.nlm.nih.gov/pubmed/34456929 http://dx.doi.org/10.3389/fimmu.2021.721738 |
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author | Bošnjak, Berislav Odak, Ivan Ritter, Christiane Stahl, Klaus Graalmann, Theresa Steinbrück, Lars Blasczyk, Rainer Falk, Christine S. Schulz, Thomas F. Wedemeyer, Hans Heinrich Cornberg, Markus Ganser, Arnold Förster, Reinhold Koenecke, Christian |
author_facet | Bošnjak, Berislav Odak, Ivan Ritter, Christiane Stahl, Klaus Graalmann, Theresa Steinbrück, Lars Blasczyk, Rainer Falk, Christine S. Schulz, Thomas F. Wedemeyer, Hans Heinrich Cornberg, Markus Ganser, Arnold Förster, Reinhold Koenecke, Christian |
author_sort | Bošnjak, Berislav |
collection | PubMed |
description | Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients. |
format | Online Article Text |
id | pubmed-8387963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83879632021-08-27 Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy Bošnjak, Berislav Odak, Ivan Ritter, Christiane Stahl, Klaus Graalmann, Theresa Steinbrück, Lars Blasczyk, Rainer Falk, Christine S. Schulz, Thomas F. Wedemeyer, Hans Heinrich Cornberg, Markus Ganser, Arnold Förster, Reinhold Koenecke, Christian Front Immunol Immunology Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients. Frontiers Media S.A. 2021-08-12 /pmc/articles/PMC8387963/ /pubmed/34456929 http://dx.doi.org/10.3389/fimmu.2021.721738 Text en Copyright © 2021 Bošnjak, Odak, Ritter, Stahl, Graalmann, Steinbrück, Blasczyk, Falk, Schulz, Wedemeyer, Cornberg, Ganser, Förster and Koenecke https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Bošnjak, Berislav Odak, Ivan Ritter, Christiane Stahl, Klaus Graalmann, Theresa Steinbrück, Lars Blasczyk, Rainer Falk, Christine S. Schulz, Thomas F. Wedemeyer, Hans Heinrich Cornberg, Markus Ganser, Arnold Förster, Reinhold Koenecke, Christian Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
title | Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
title_full | Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
title_fullStr | Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
title_full_unstemmed | Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
title_short | Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy |
title_sort | case report: convalescent plasma therapy induced anti-sars-cov-2 t cell expansion, nk cell maturation and virus clearance in a b cell deficient patient after cd19 car t cell therapy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387963/ https://www.ncbi.nlm.nih.gov/pubmed/34456929 http://dx.doi.org/10.3389/fimmu.2021.721738 |
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