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Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy

Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with...

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Autores principales: Bošnjak, Berislav, Odak, Ivan, Ritter, Christiane, Stahl, Klaus, Graalmann, Theresa, Steinbrück, Lars, Blasczyk, Rainer, Falk, Christine S., Schulz, Thomas F., Wedemeyer, Hans Heinrich, Cornberg, Markus, Ganser, Arnold, Förster, Reinhold, Koenecke, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387963/
https://www.ncbi.nlm.nih.gov/pubmed/34456929
http://dx.doi.org/10.3389/fimmu.2021.721738
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author Bošnjak, Berislav
Odak, Ivan
Ritter, Christiane
Stahl, Klaus
Graalmann, Theresa
Steinbrück, Lars
Blasczyk, Rainer
Falk, Christine S.
Schulz, Thomas F.
Wedemeyer, Hans Heinrich
Cornberg, Markus
Ganser, Arnold
Förster, Reinhold
Koenecke, Christian
author_facet Bošnjak, Berislav
Odak, Ivan
Ritter, Christiane
Stahl, Klaus
Graalmann, Theresa
Steinbrück, Lars
Blasczyk, Rainer
Falk, Christine S.
Schulz, Thomas F.
Wedemeyer, Hans Heinrich
Cornberg, Markus
Ganser, Arnold
Förster, Reinhold
Koenecke, Christian
author_sort Bošnjak, Berislav
collection PubMed
description Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients.
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spelling pubmed-83879632021-08-27 Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy Bošnjak, Berislav Odak, Ivan Ritter, Christiane Stahl, Klaus Graalmann, Theresa Steinbrück, Lars Blasczyk, Rainer Falk, Christine S. Schulz, Thomas F. Wedemeyer, Hans Heinrich Cornberg, Markus Ganser, Arnold Förster, Reinhold Koenecke, Christian Front Immunol Immunology Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients. Frontiers Media S.A. 2021-08-12 /pmc/articles/PMC8387963/ /pubmed/34456929 http://dx.doi.org/10.3389/fimmu.2021.721738 Text en Copyright © 2021 Bošnjak, Odak, Ritter, Stahl, Graalmann, Steinbrück, Blasczyk, Falk, Schulz, Wedemeyer, Cornberg, Ganser, Förster and Koenecke https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Bošnjak, Berislav
Odak, Ivan
Ritter, Christiane
Stahl, Klaus
Graalmann, Theresa
Steinbrück, Lars
Blasczyk, Rainer
Falk, Christine S.
Schulz, Thomas F.
Wedemeyer, Hans Heinrich
Cornberg, Markus
Ganser, Arnold
Förster, Reinhold
Koenecke, Christian
Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy
title Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy
title_full Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy
title_fullStr Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy
title_full_unstemmed Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy
title_short Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy
title_sort case report: convalescent plasma therapy induced anti-sars-cov-2 t cell expansion, nk cell maturation and virus clearance in a b cell deficient patient after cd19 car t cell therapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387963/
https://www.ncbi.nlm.nih.gov/pubmed/34456929
http://dx.doi.org/10.3389/fimmu.2021.721738
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