Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans

For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of population genetics and of sequencing data in the design of g...

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Detalles Bibliográficos
Autores principales: Kehdy, Fernanda S.G., Pita-Oliveira, Murilo, Scudeler, Mariana M., Torres-Loureiro, Sabrina, Zolini, Camila, Moreira, Rennan, Michelin, Lucas A., Alvim, Isabela, Silva-Carvalho, Carolina, Furlan, Vinicius C., Aquino, Marla M., Santolalla, Meddly L., Borda, Victor, Soares-Souza, Giordano B., Jaramillo-Valverde, Luis, Vasquez-Dominguez, Andres, Neira, Cesar Sanchez, Aguiar, Renato S., Verdugo, Ricardo A., O`Connor, Timothy D., Guio, Heinner, Tarazona-Santos, Eduardo, Leal, Thiago P., Rodrigues-Soares, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387978/
https://www.ncbi.nlm.nih.gov/pubmed/34436507
http://dx.doi.org/10.1590/1678-4685-GMB-2020-0484

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