The Roles of Alternative Splicing in Tumor-immune Cell Interactions

Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-media...

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Autores principales: Wang, Yue, Zhang, Honglei, Jiao, Baowei, Nie, Jianyun, Li, Xiyin, Wang, Wenhuan, Wang, Hairui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388066/
https://www.ncbi.nlm.nih.gov/pubmed/32560607
http://dx.doi.org/10.2174/1568009620666200619123725
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author Wang, Yue
Zhang, Honglei
Jiao, Baowei
Nie, Jianyun
Li, Xiyin
Wang, Wenhuan
Wang, Hairui
author_facet Wang, Yue
Zhang, Honglei
Jiao, Baowei
Nie, Jianyun
Li, Xiyin
Wang, Wenhuan
Wang, Hairui
author_sort Wang, Yue
collection PubMed
description Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and pro-tumoral roles in different types of cancer. For example, ULBP1_RI, MLL5△21spe, NKp44-1△5, MHC-I△7, CD200S△1, 2, PVR α/β/γ/δ and IL-33 variants 1/2/3 act as regulators in solid tumors and IPAK4-L and, FOXP1ΔN100 exhibit functions in hematological cancers.
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spelling pubmed-83880662021-09-07 The Roles of Alternative Splicing in Tumor-immune Cell Interactions Wang, Yue Zhang, Honglei Jiao, Baowei Nie, Jianyun Li, Xiyin Wang, Wenhuan Wang, Hairui Anticancer Agents Med Chem Article Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and pro-tumoral roles in different types of cancer. For example, ULBP1_RI, MLL5△21spe, NKp44-1△5, MHC-I△7, CD200S△1, 2, PVR α/β/γ/δ and IL-33 variants 1/2/3 act as regulators in solid tumors and IPAK4-L and, FOXP1ΔN100 exhibit functions in hematological cancers. Bentham Science Publishers 2020-11 2020-11 /pmc/articles/PMC8388066/ /pubmed/32560607 http://dx.doi.org/10.2174/1568009620666200619123725 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Wang, Yue
Zhang, Honglei
Jiao, Baowei
Nie, Jianyun
Li, Xiyin
Wang, Wenhuan
Wang, Hairui
The Roles of Alternative Splicing in Tumor-immune Cell Interactions
title The Roles of Alternative Splicing in Tumor-immune Cell Interactions
title_full The Roles of Alternative Splicing in Tumor-immune Cell Interactions
title_fullStr The Roles of Alternative Splicing in Tumor-immune Cell Interactions
title_full_unstemmed The Roles of Alternative Splicing in Tumor-immune Cell Interactions
title_short The Roles of Alternative Splicing in Tumor-immune Cell Interactions
title_sort roles of alternative splicing in tumor-immune cell interactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388066/
https://www.ncbi.nlm.nih.gov/pubmed/32560607
http://dx.doi.org/10.2174/1568009620666200619123725
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