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An immunogenetic view of COVID-19
Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogen...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Genética
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388242/ https://www.ncbi.nlm.nih.gov/pubmed/34436508 http://dx.doi.org/10.1590/1678-4685-GMB-2021-0036 |
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author | Aguiar, Vitor R. C. Augusto, Danillo G. Castelli, Erick C. Hollenbach, Jill A. Meyer, Diogo Nunes, Kelly Petzl-Erler, Maria Luiza |
author_facet | Aguiar, Vitor R. C. Augusto, Danillo G. Castelli, Erick C. Hollenbach, Jill A. Meyer, Diogo Nunes, Kelly Petzl-Erler, Maria Luiza |
author_sort | Aguiar, Vitor R. C. |
collection | PubMed |
description | Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogeneity of susceptibility and protection to the viral infection and disease progression. Here, we review the knowledge developed so far, discussing fundamental genes for triggering the innate and adaptive immune responses associated with a viral infection, especially with the SARS-CoV-2 mechanisms. We emphasize the role of the HLA and KIR genes, discussing what has been uncovered about their role in COVID-19 and addressing methodological challenges of studying these genes. Finally, we comment on questions that arise when studying admixed populations, highlighting the case of Brazil. We argue that the interplay between immunology and an understanding of genetic associations can provide an important contribution to our knowledge of COVID-19. |
format | Online Article Text |
id | pubmed-8388242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-83882422021-08-31 An immunogenetic view of COVID-19 Aguiar, Vitor R. C. Augusto, Danillo G. Castelli, Erick C. Hollenbach, Jill A. Meyer, Diogo Nunes, Kelly Petzl-Erler, Maria Luiza Genet Mol Biol Articles Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogeneity of susceptibility and protection to the viral infection and disease progression. Here, we review the knowledge developed so far, discussing fundamental genes for triggering the innate and adaptive immune responses associated with a viral infection, especially with the SARS-CoV-2 mechanisms. We emphasize the role of the HLA and KIR genes, discussing what has been uncovered about their role in COVID-19 and addressing methodological challenges of studying these genes. Finally, we comment on questions that arise when studying admixed populations, highlighting the case of Brazil. We argue that the interplay between immunology and an understanding of genetic associations can provide an important contribution to our knowledge of COVID-19. Sociedade Brasileira de Genética 2021-08-25 /pmc/articles/PMC8388242/ /pubmed/34436508 http://dx.doi.org/10.1590/1678-4685-GMB-2021-0036 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Articles Aguiar, Vitor R. C. Augusto, Danillo G. Castelli, Erick C. Hollenbach, Jill A. Meyer, Diogo Nunes, Kelly Petzl-Erler, Maria Luiza An immunogenetic view of COVID-19 |
title | An immunogenetic view of COVID-19 |
title_full | An immunogenetic view of COVID-19 |
title_fullStr | An immunogenetic view of COVID-19 |
title_full_unstemmed | An immunogenetic view of COVID-19 |
title_short | An immunogenetic view of COVID-19 |
title_sort | immunogenetic view of covid-19 |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388242/ https://www.ncbi.nlm.nih.gov/pubmed/34436508 http://dx.doi.org/10.1590/1678-4685-GMB-2021-0036 |
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