Cargando…

Effects of moxibustion on reproduction and metabolism of polycystic ovary syndrome: a protocol for meta-analysis and systematic review

INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy in women of reproductive age. Recently, moxibustion, as a complementary and alternative therapy, has been commonly used in assisted reproduction and improvement of metabolic abnormalities in patients with PCOS. C...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Kou, Wang, Jiajie, Hu, Feng, Lv, Siying, Zhang, Yanji, Yang, Qiqi, Huang, Wei, Zhou, Zhongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388304/
https://www.ncbi.nlm.nih.gov/pubmed/34433602
http://dx.doi.org/10.1136/bmjopen-2021-049039
_version_ 1783742612518207488
author Xu, Kou
Wang, Jiajie
Hu, Feng
Lv, Siying
Zhang, Yanji
Yang, Qiqi
Huang, Wei
Zhou, Zhongyu
author_facet Xu, Kou
Wang, Jiajie
Hu, Feng
Lv, Siying
Zhang, Yanji
Yang, Qiqi
Huang, Wei
Zhou, Zhongyu
author_sort Xu, Kou
collection PubMed
description INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy in women of reproductive age. Recently, moxibustion, as a complementary and alternative therapy, has been commonly used in assisted reproduction and improvement of metabolic abnormalities in patients with PCOS. Currently, intervention efficacy of the use of moxibustion in PCOS treatment still remains controversial due to lack of high-quality evidence. Consequently, this study protocol was designed to objectively review and evaluate the effectiveness and safety of moxibustion treatment for PCOS. METHODS AND ANALYSIS: Electronic searches will be carried out from inception to May 2021 in the online databases of The Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature, Chongqing VIP Chinese Science and Technology Periodical Database (VIP) and China National Knowledge Infrastructure. The Chinese Clinical Trial Registry Center and Clinical Trials will be used for searching ongoing trials. Randomised controlled trials and the first period in randomised cross-over trials involving any type of moxibustion for patients with PCOS will be included. Primary outcomes will be the ovulation rate, pregnancy rate and sex hormone levels, and secondary outcomes will be changes in clinical symptoms and metabolic indicators, total effective rate and the incidences of side effects and adverse events. Briefly, two reviewers will independently conduct study selection and data extraction, and the risk of bias will be assessed. Prior to the formal meta-analysis, the heterogeneity of included studies will be assessed. Review Manager Statistical Software (RevMan) V.5.3 will be used for data processing. Finally, the Grading of Recommendations Assessment, Development and Evaluation method will be applied to evaluate the quality of evidence. ETHICS AND DISSEMINATION: Ethical approval is not necessary since this study is designed as a systematic review. This study will be disseminated by a peer-review journal or conference presentation.
format Online
Article
Text
id pubmed-8388304
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-83883042021-09-14 Effects of moxibustion on reproduction and metabolism of polycystic ovary syndrome: a protocol for meta-analysis and systematic review Xu, Kou Wang, Jiajie Hu, Feng Lv, Siying Zhang, Yanji Yang, Qiqi Huang, Wei Zhou, Zhongyu BMJ Open Obstetrics and Gynaecology INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy in women of reproductive age. Recently, moxibustion, as a complementary and alternative therapy, has been commonly used in assisted reproduction and improvement of metabolic abnormalities in patients with PCOS. Currently, intervention efficacy of the use of moxibustion in PCOS treatment still remains controversial due to lack of high-quality evidence. Consequently, this study protocol was designed to objectively review and evaluate the effectiveness and safety of moxibustion treatment for PCOS. METHODS AND ANALYSIS: Electronic searches will be carried out from inception to May 2021 in the online databases of The Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature, Chongqing VIP Chinese Science and Technology Periodical Database (VIP) and China National Knowledge Infrastructure. The Chinese Clinical Trial Registry Center and Clinical Trials will be used for searching ongoing trials. Randomised controlled trials and the first period in randomised cross-over trials involving any type of moxibustion for patients with PCOS will be included. Primary outcomes will be the ovulation rate, pregnancy rate and sex hormone levels, and secondary outcomes will be changes in clinical symptoms and metabolic indicators, total effective rate and the incidences of side effects and adverse events. Briefly, two reviewers will independently conduct study selection and data extraction, and the risk of bias will be assessed. Prior to the formal meta-analysis, the heterogeneity of included studies will be assessed. Review Manager Statistical Software (RevMan) V.5.3 will be used for data processing. Finally, the Grading of Recommendations Assessment, Development and Evaluation method will be applied to evaluate the quality of evidence. ETHICS AND DISSEMINATION: Ethical approval is not necessary since this study is designed as a systematic review. This study will be disseminated by a peer-review journal or conference presentation. BMJ Publishing Group 2021-08-25 /pmc/articles/PMC8388304/ /pubmed/34433602 http://dx.doi.org/10.1136/bmjopen-2021-049039 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Obstetrics and Gynaecology
Xu, Kou
Wang, Jiajie
Hu, Feng
Lv, Siying
Zhang, Yanji
Yang, Qiqi
Huang, Wei
Zhou, Zhongyu
Effects of moxibustion on reproduction and metabolism of polycystic ovary syndrome: a protocol for meta-analysis and systematic review
title Effects of moxibustion on reproduction and metabolism of polycystic ovary syndrome: a protocol for meta-analysis and systematic review
title_full Effects of moxibustion on reproduction and metabolism of polycystic ovary syndrome: a protocol for meta-analysis and systematic review
title_fullStr Effects of moxibustion on reproduction and metabolism of polycystic ovary syndrome: a protocol for meta-analysis and systematic review
title_full_unstemmed Effects of moxibustion on reproduction and metabolism of polycystic ovary syndrome: a protocol for meta-analysis and systematic review
title_short Effects of moxibustion on reproduction and metabolism of polycystic ovary syndrome: a protocol for meta-analysis and systematic review
title_sort effects of moxibustion on reproduction and metabolism of polycystic ovary syndrome: a protocol for meta-analysis and systematic review
topic Obstetrics and Gynaecology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388304/
https://www.ncbi.nlm.nih.gov/pubmed/34433602
http://dx.doi.org/10.1136/bmjopen-2021-049039
work_keys_str_mv AT xukou effectsofmoxibustiononreproductionandmetabolismofpolycysticovarysyndromeaprotocolformetaanalysisandsystematicreview
AT wangjiajie effectsofmoxibustiononreproductionandmetabolismofpolycysticovarysyndromeaprotocolformetaanalysisandsystematicreview
AT hufeng effectsofmoxibustiononreproductionandmetabolismofpolycysticovarysyndromeaprotocolformetaanalysisandsystematicreview
AT lvsiying effectsofmoxibustiononreproductionandmetabolismofpolycysticovarysyndromeaprotocolformetaanalysisandsystematicreview
AT zhangyanji effectsofmoxibustiononreproductionandmetabolismofpolycysticovarysyndromeaprotocolformetaanalysisandsystematicreview
AT yangqiqi effectsofmoxibustiononreproductionandmetabolismofpolycysticovarysyndromeaprotocolformetaanalysisandsystematicreview
AT huangwei effectsofmoxibustiononreproductionandmetabolismofpolycysticovarysyndromeaprotocolformetaanalysisandsystematicreview
AT zhouzhongyu effectsofmoxibustiononreproductionandmetabolismofpolycysticovarysyndromeaprotocolformetaanalysisandsystematicreview