Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia

RNA binding proteins (RBPs) are key arbiters of post-transcriptional regulation and are found to be found dysregulated in hematological malignancies. Here, we identify the RBP RBMX and its retrogene RBMXL1 to be required for murine and human myeloid leukemogenesis. RBMX/L1 are overexpressed in acute...

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Detalles Bibliográficos
Autores principales: Prieto, Camila, Nguyen, Diu T T, Liu, Zhaoqi, Wheat, Justin, Perez, Alexendar, Gourkanti, Saroj, Chou, Timothy, Barin, Ersilia, Velleca, Anthony, Rohwetter, Thomas, Chow, Arthur, Taggart, James, Savino, Angela M, Hoskova, Katerina, Dhodapkar, Meera, Schurer, Alexandra, Barlowe, Trevor S, Vu, Ly P, Leslie, Christina, Steidl, Ulrich, Rabadan, Raul, Kharas, Michael G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388313/
https://www.ncbi.nlm.nih.gov/pubmed/34458856
http://dx.doi.org/10.1038/s43018-021-00220-w

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