Acid-Sensing Ion Channels in Zebrafish

SIMPLE SUMMARY: The present review collects data regarding the presence of ASICs (acid-sensing ion channels) in zebrafish, which have become, over several years, an important experimental model for the study of various diseases. ASICs are a family of ion channels involved in the perception of different types of stimuli. They are excitatory receptors for extracellular H(+) involved in synaptic transmission, the peripheral perception of pain and in chemical or mechanosensation. ABSTRACT: The ASICs, in mammals as in fish, control deviations from the physiological values of extracellular pH, and are involved in mechanoreception, nociception, or taste receptions. They are widely expressed in the central and peripheral nervous system. In this review, we summarized the data about the presence and localization of ASICs in different organs of zebrafish that represent one of the most used experimental models for the study of several diseases. In particular, we analyzed the data obtained by immunohistochemical and molecular biology techniques concerning the presence and expression of ASICs in the sensory organs, such as the olfactory rosette, lateral line, inner ear, taste buds, and in the gut and brain of zebrafish.