Cationic Peptidomimetic Amphiphiles Having a N-Aryl- or N-Naphthyl-1,2,3-Triazole Core Structure Targeting Clostridioides (Clostridium) difficile: Synthesis, Antibacterial Evaluation, and an In Vivo C. difficile Infection Model

Clostridioides (also known as Clostridium) difficile is a Gram-positive anaerobic, spore producing bacterial pathogen that causes severe gastrointestinal infection in humans. The current chemotherapeutic options are inadequate, expensive, and limited, and thus inexpensive drug treatments for C. diff...

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Detalles Bibliográficos
Autores principales: Mahadari, Muni Kumar, Jennepalli, Sreenu, Tague, Andrew J., Putsathit, Papanin, Hutton, Melanie L., Hammer, Katherine A., Knight, Daniel R., Riley, Thomas V., Lyras, Dena, Keller, Paul A., Pyne, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388771/
https://www.ncbi.nlm.nih.gov/pubmed/34438963
http://dx.doi.org/10.3390/antibiotics10080913

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