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Aryl Coenzyme A Ligases, a Subfamily of the Adenylate-Forming Enzyme Superfamily

Aryl coenzyme A (CoA) ligases belong to class I of the adenylate-forming enzyme superfamily (ANL superfamily). They catalyze the formation of thioester bonds between aromatic compounds and CoA and occur in nearly all forms of life. These ligases are involved in various metabolic pathways degrading b...

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Autores principales: Arnold, M. E., Kaplieva-Dudek, I., Heker, I., Meckenstock, R. U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388817/
https://www.ncbi.nlm.nih.gov/pubmed/34260306
http://dx.doi.org/10.1128/AEM.00690-21
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author Arnold, M. E.
Kaplieva-Dudek, I.
Heker, I.
Meckenstock, R. U.
author_facet Arnold, M. E.
Kaplieva-Dudek, I.
Heker, I.
Meckenstock, R. U.
author_sort Arnold, M. E.
collection PubMed
description Aryl coenzyme A (CoA) ligases belong to class I of the adenylate-forming enzyme superfamily (ANL superfamily). They catalyze the formation of thioester bonds between aromatic compounds and CoA and occur in nearly all forms of life. These ligases are involved in various metabolic pathways degrading benzene, toluene, ethylbenzene, and xylene (BTEX) or polycyclic aromatic hydrocarbons (PAHs). They are often necessary to produce the central intermediate benzoyl-CoA that occurs in various anaerobic pathways. The substrate specificity is very diverse between enzymes within the same class, while the dependency on Mg(2+), ATP, and CoA as well as oxygen insensitivity are characteristics shared by the whole enzyme class. Some organisms employ the same aryl-CoA ligase when growing aerobically and anaerobically, while others induce different enzymes depending on the environmental conditions. Aryl-CoA ligases can be divided into two major groups, benzoate:CoA ligase-like enzymes and phenylacetate:CoA ligase-like enzymes. They are widely distributed between the phylogenetic clades of the ANL superfamily and show closer relationships within the subfamilies than to other aryl-CoA ligases. This, together with residual CoA ligase activity in various other enzymes of the ANL superfamily, leads to the conclusion that CoA ligases might be the ancestral proteins from which all other ANL superfamily enzymes developed.
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spelling pubmed-83888172021-09-13 Aryl Coenzyme A Ligases, a Subfamily of the Adenylate-Forming Enzyme Superfamily Arnold, M. E. Kaplieva-Dudek, I. Heker, I. Meckenstock, R. U. Appl Environ Microbiol Minireview Aryl coenzyme A (CoA) ligases belong to class I of the adenylate-forming enzyme superfamily (ANL superfamily). They catalyze the formation of thioester bonds between aromatic compounds and CoA and occur in nearly all forms of life. These ligases are involved in various metabolic pathways degrading benzene, toluene, ethylbenzene, and xylene (BTEX) or polycyclic aromatic hydrocarbons (PAHs). They are often necessary to produce the central intermediate benzoyl-CoA that occurs in various anaerobic pathways. The substrate specificity is very diverse between enzymes within the same class, while the dependency on Mg(2+), ATP, and CoA as well as oxygen insensitivity are characteristics shared by the whole enzyme class. Some organisms employ the same aryl-CoA ligase when growing aerobically and anaerobically, while others induce different enzymes depending on the environmental conditions. Aryl-CoA ligases can be divided into two major groups, benzoate:CoA ligase-like enzymes and phenylacetate:CoA ligase-like enzymes. They are widely distributed between the phylogenetic clades of the ANL superfamily and show closer relationships within the subfamilies than to other aryl-CoA ligases. This, together with residual CoA ligase activity in various other enzymes of the ANL superfamily, leads to the conclusion that CoA ligases might be the ancestral proteins from which all other ANL superfamily enzymes developed. American Society for Microbiology 2021-08-26 /pmc/articles/PMC8388817/ /pubmed/34260306 http://dx.doi.org/10.1128/AEM.00690-21 Text en Copyright © 2021 Arnold et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Minireview
Arnold, M. E.
Kaplieva-Dudek, I.
Heker, I.
Meckenstock, R. U.
Aryl Coenzyme A Ligases, a Subfamily of the Adenylate-Forming Enzyme Superfamily
title Aryl Coenzyme A Ligases, a Subfamily of the Adenylate-Forming Enzyme Superfamily
title_full Aryl Coenzyme A Ligases, a Subfamily of the Adenylate-Forming Enzyme Superfamily
title_fullStr Aryl Coenzyme A Ligases, a Subfamily of the Adenylate-Forming Enzyme Superfamily
title_full_unstemmed Aryl Coenzyme A Ligases, a Subfamily of the Adenylate-Forming Enzyme Superfamily
title_short Aryl Coenzyme A Ligases, a Subfamily of the Adenylate-Forming Enzyme Superfamily
title_sort aryl coenzyme a ligases, a subfamily of the adenylate-forming enzyme superfamily
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388817/
https://www.ncbi.nlm.nih.gov/pubmed/34260306
http://dx.doi.org/10.1128/AEM.00690-21
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