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Antimicrobial Potential of Microorganisms Isolated from the Bottom Sediments of Lake Baikal
Extremophilic microorganisms attract researchers by their unique characteristics, primarily antagonistic ones, acquired in the process of survival in extreme natural conditions. The antimicrobial potential of the metabolites of these microorganisms is quite broad, from the food industry to therapeut...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388859/ https://www.ncbi.nlm.nih.gov/pubmed/34438977 http://dx.doi.org/10.3390/antibiotics10080927 |
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author | Babich, Olga Shevchenko, Margarita Ivanova, Svetlana Pavsky, Valery Zimina, Maria Noskova, Svetlana Anohova, Veronika Chupakhin, Evgeny Sukhikh, Stanislav |
author_facet | Babich, Olga Shevchenko, Margarita Ivanova, Svetlana Pavsky, Valery Zimina, Maria Noskova, Svetlana Anohova, Veronika Chupakhin, Evgeny Sukhikh, Stanislav |
author_sort | Babich, Olga |
collection | PubMed |
description | Extremophilic microorganisms attract researchers by their unique characteristics, primarily antagonistic ones, acquired in the process of survival in extreme natural conditions. The antimicrobial potential of the metabolites of these microorganisms is quite broad, from the food industry to therapeutic drugs. Microbial mats of Lake Baikal are a source of unique and diverse microorganisms. The study aimed to evaluate the antimicrobial activity of bacterial strains isolated from the bottom sediments of the lake. Using heterotrophic growth conditions, seven bacterial strains were isolated from samples collected in several coastal zones of Lake Baikal. Thisstudy identified both widespread strains of the genera Pseudomonas and Bacillus and rare genera Micrococcus and Acinetobacterrepresentatives. Metabolites of five strains were found to have a broad spectrum of antimicrobial activity. Four large fractions of metabolites of the isolated strains wereidentified. Two peptides of the isolated fractions of metabolites (one is produced by microorganisms of all five isolated strains, another—only by Pseudomonas putida) are low molecular weight oligopeptides. These peptides were proved to be bacteriocins. |
format | Online Article Text |
id | pubmed-8388859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83888592021-08-27 Antimicrobial Potential of Microorganisms Isolated from the Bottom Sediments of Lake Baikal Babich, Olga Shevchenko, Margarita Ivanova, Svetlana Pavsky, Valery Zimina, Maria Noskova, Svetlana Anohova, Veronika Chupakhin, Evgeny Sukhikh, Stanislav Antibiotics (Basel) Article Extremophilic microorganisms attract researchers by their unique characteristics, primarily antagonistic ones, acquired in the process of survival in extreme natural conditions. The antimicrobial potential of the metabolites of these microorganisms is quite broad, from the food industry to therapeutic drugs. Microbial mats of Lake Baikal are a source of unique and diverse microorganisms. The study aimed to evaluate the antimicrobial activity of bacterial strains isolated from the bottom sediments of the lake. Using heterotrophic growth conditions, seven bacterial strains were isolated from samples collected in several coastal zones of Lake Baikal. Thisstudy identified both widespread strains of the genera Pseudomonas and Bacillus and rare genera Micrococcus and Acinetobacterrepresentatives. Metabolites of five strains were found to have a broad spectrum of antimicrobial activity. Four large fractions of metabolites of the isolated strains wereidentified. Two peptides of the isolated fractions of metabolites (one is produced by microorganisms of all five isolated strains, another—only by Pseudomonas putida) are low molecular weight oligopeptides. These peptides were proved to be bacteriocins. MDPI 2021-07-30 /pmc/articles/PMC8388859/ /pubmed/34438977 http://dx.doi.org/10.3390/antibiotics10080927 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Babich, Olga Shevchenko, Margarita Ivanova, Svetlana Pavsky, Valery Zimina, Maria Noskova, Svetlana Anohova, Veronika Chupakhin, Evgeny Sukhikh, Stanislav Antimicrobial Potential of Microorganisms Isolated from the Bottom Sediments of Lake Baikal |
title | Antimicrobial Potential of Microorganisms Isolated from the Bottom Sediments of Lake Baikal |
title_full | Antimicrobial Potential of Microorganisms Isolated from the Bottom Sediments of Lake Baikal |
title_fullStr | Antimicrobial Potential of Microorganisms Isolated from the Bottom Sediments of Lake Baikal |
title_full_unstemmed | Antimicrobial Potential of Microorganisms Isolated from the Bottom Sediments of Lake Baikal |
title_short | Antimicrobial Potential of Microorganisms Isolated from the Bottom Sediments of Lake Baikal |
title_sort | antimicrobial potential of microorganisms isolated from the bottom sediments of lake baikal |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388859/ https://www.ncbi.nlm.nih.gov/pubmed/34438977 http://dx.doi.org/10.3390/antibiotics10080927 |
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