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The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)

Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating...

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Autores principales: Caldas, María, Pérez-Aisa, Ángeles, Tepes, Bojan, Keco-Huerga, Alma, Bujanda, Luis, Lucendo, Alfredo J., Rodrigo, Luis, Vaira, Dino, Fernández-Salazar, Luis, Huguet, Jose M., Pérez-Lasala, Jorge, Jurecic, Natasa Brglez, Fadeenko, Galina, Barrio, Jesús, Areia, Miguel, Ortuño, Juan, Pellicano, Rinaldo, Leja, Marcis, Molina-Infante, Javier, Bogomolov, Pavel, Alekseenko, Sergey, Domínguez-Cajal, Manuel, Gómez-Camarero, Judith, Ntouli, Vassiliki, Martínez-Domínguez, Samuel J., Ruiz-Zorrilla, Rafael, Núñez, Oscar, Sarsenbaeva, Aiman Silkanovna, Almela, Pedro, Phull, Perminder, Espada, Marta, Puig, Ignasi, Nyssen, Olga P., Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., Investigators, on behalf of the Hp-EuReg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388917/
https://www.ncbi.nlm.nih.gov/pubmed/34439015
http://dx.doi.org/10.3390/antibiotics10080965
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author Caldas, María
Pérez-Aisa, Ángeles
Tepes, Bojan
Keco-Huerga, Alma
Bujanda, Luis
Lucendo, Alfredo J.
Rodrigo, Luis
Vaira, Dino
Fernández-Salazar, Luis
Huguet, Jose M.
Pérez-Lasala, Jorge
Jurecic, Natasa Brglez
Fadeenko, Galina
Barrio, Jesús
Areia, Miguel
Ortuño, Juan
Pellicano, Rinaldo
Leja, Marcis
Molina-Infante, Javier
Bogomolov, Pavel
Alekseenko, Sergey
Domínguez-Cajal, Manuel
Gómez-Camarero, Judith
Ntouli, Vassiliki
Martínez-Domínguez, Samuel J.
Ruiz-Zorrilla, Rafael
Núñez, Oscar
Sarsenbaeva, Aiman Silkanovna
Almela, Pedro
Phull, Perminder
Espada, Marta
Puig, Ignasi
Nyssen, Olga P.
Mégraud, Francis
O’Morain, Colm
Gisbert, Javier P.
Investigators, on behalf of the Hp-EuReg
author_facet Caldas, María
Pérez-Aisa, Ángeles
Tepes, Bojan
Keco-Huerga, Alma
Bujanda, Luis
Lucendo, Alfredo J.
Rodrigo, Luis
Vaira, Dino
Fernández-Salazar, Luis
Huguet, Jose M.
Pérez-Lasala, Jorge
Jurecic, Natasa Brglez
Fadeenko, Galina
Barrio, Jesús
Areia, Miguel
Ortuño, Juan
Pellicano, Rinaldo
Leja, Marcis
Molina-Infante, Javier
Bogomolov, Pavel
Alekseenko, Sergey
Domínguez-Cajal, Manuel
Gómez-Camarero, Judith
Ntouli, Vassiliki
Martínez-Domínguez, Samuel J.
Ruiz-Zorrilla, Rafael
Núñez, Oscar
Sarsenbaeva, Aiman Silkanovna
Almela, Pedro
Phull, Perminder
Espada, Marta
Puig, Ignasi
Nyssen, Olga P.
Mégraud, Francis
O’Morain, Colm
Gisbert, Javier P.
Investigators, on behalf of the Hp-EuReg
author_sort Caldas, María
collection PubMed
description Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating the management of H. pylori by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap from 2013 to 2020. The association between statin use and H. pylori eradication effectiveness was evaluated through multivariate analysis. Overall, 9988 and 705 patients received empirical and culture-guided treatment, respectively. Overall, statin use was associated with higher effectiveness in the empirical group (OR = 1.3; 95%CI = 1.1–1.5), but no association was found with first-line treatment effectiveness (N = 7738); as an exception, statin use was specifically associated with lower effectiveness of standard triple therapy (OR = 0.76; 95%CI = 0.59–0.99). In the rescue therapy empirical group (N = 2228), statins were associated with higher overall effectiveness (OR = 1.9; 95%CI = 1.4–2.6). However, sub-analyses by treatment schemes only confirmed this association for the single-capsule bismuth quadruple therapy (OR = 2.8; 95%CI = 1.3–5.7). No consistent association was found between statin use and H. pylori therapy effectiveness. Therefore, the addition of statins to the usual H. pylori treatment cannot be currently recommended to improve cure rates.
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spelling pubmed-83889172021-08-27 The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg) Caldas, María Pérez-Aisa, Ángeles Tepes, Bojan Keco-Huerga, Alma Bujanda, Luis Lucendo, Alfredo J. Rodrigo, Luis Vaira, Dino Fernández-Salazar, Luis Huguet, Jose M. Pérez-Lasala, Jorge Jurecic, Natasa Brglez Fadeenko, Galina Barrio, Jesús Areia, Miguel Ortuño, Juan Pellicano, Rinaldo Leja, Marcis Molina-Infante, Javier Bogomolov, Pavel Alekseenko, Sergey Domínguez-Cajal, Manuel Gómez-Camarero, Judith Ntouli, Vassiliki Martínez-Domínguez, Samuel J. Ruiz-Zorrilla, Rafael Núñez, Oscar Sarsenbaeva, Aiman Silkanovna Almela, Pedro Phull, Perminder Espada, Marta Puig, Ignasi Nyssen, Olga P. Mégraud, Francis O’Morain, Colm Gisbert, Javier P. Investigators, on behalf of the Hp-EuReg Antibiotics (Basel) Article Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating the management of H. pylori by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap from 2013 to 2020. The association between statin use and H. pylori eradication effectiveness was evaluated through multivariate analysis. Overall, 9988 and 705 patients received empirical and culture-guided treatment, respectively. Overall, statin use was associated with higher effectiveness in the empirical group (OR = 1.3; 95%CI = 1.1–1.5), but no association was found with first-line treatment effectiveness (N = 7738); as an exception, statin use was specifically associated with lower effectiveness of standard triple therapy (OR = 0.76; 95%CI = 0.59–0.99). In the rescue therapy empirical group (N = 2228), statins were associated with higher overall effectiveness (OR = 1.9; 95%CI = 1.4–2.6). However, sub-analyses by treatment schemes only confirmed this association for the single-capsule bismuth quadruple therapy (OR = 2.8; 95%CI = 1.3–5.7). No consistent association was found between statin use and H. pylori therapy effectiveness. Therefore, the addition of statins to the usual H. pylori treatment cannot be currently recommended to improve cure rates. MDPI 2021-08-11 /pmc/articles/PMC8388917/ /pubmed/34439015 http://dx.doi.org/10.3390/antibiotics10080965 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Caldas, María
Pérez-Aisa, Ángeles
Tepes, Bojan
Keco-Huerga, Alma
Bujanda, Luis
Lucendo, Alfredo J.
Rodrigo, Luis
Vaira, Dino
Fernández-Salazar, Luis
Huguet, Jose M.
Pérez-Lasala, Jorge
Jurecic, Natasa Brglez
Fadeenko, Galina
Barrio, Jesús
Areia, Miguel
Ortuño, Juan
Pellicano, Rinaldo
Leja, Marcis
Molina-Infante, Javier
Bogomolov, Pavel
Alekseenko, Sergey
Domínguez-Cajal, Manuel
Gómez-Camarero, Judith
Ntouli, Vassiliki
Martínez-Domínguez, Samuel J.
Ruiz-Zorrilla, Rafael
Núñez, Oscar
Sarsenbaeva, Aiman Silkanovna
Almela, Pedro
Phull, Perminder
Espada, Marta
Puig, Ignasi
Nyssen, Olga P.
Mégraud, Francis
O’Morain, Colm
Gisbert, Javier P.
Investigators, on behalf of the Hp-EuReg
The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)
title The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)
title_full The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)
title_fullStr The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)
title_full_unstemmed The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)
title_short The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg)
title_sort role of statins on helicobacter pylori eradication: results from the european registry on the management of h. pylori (hp-eureg)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388917/
https://www.ncbi.nlm.nih.gov/pubmed/34439015
http://dx.doi.org/10.3390/antibiotics10080965
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