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Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits

Ursolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a number of traditional Chinese medicinal plants. UA has a broad range of biological activities and numerous potential health benefits. In this review, we summarize the current data on the bioavailability...

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Autores principales: Nguyen, Huynh Nga, Ullevig, Sarah L., Short, John D., Wang, Luxi, Ahn, Yong Joo, Asmis, Reto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388988/
https://www.ncbi.nlm.nih.gov/pubmed/34439409
http://dx.doi.org/10.3390/antiox10081161
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author Nguyen, Huynh Nga
Ullevig, Sarah L.
Short, John D.
Wang, Luxi
Ahn, Yong Joo
Asmis, Reto
author_facet Nguyen, Huynh Nga
Ullevig, Sarah L.
Short, John D.
Wang, Luxi
Ahn, Yong Joo
Asmis, Reto
author_sort Nguyen, Huynh Nga
collection PubMed
description Ursolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a number of traditional Chinese medicinal plants. UA has a broad range of biological activities and numerous potential health benefits. In this review, we summarize the current data on the bioavailability and pharmacokinetics of UA and review the literature on the biological activities of UA and its closest analogues in the context of inflammation, metabolic diseases, including liver and kidney diseases, obesity and diabetes, cardiovascular diseases, cancer, and neurological disorders. We end with a brief overview of UA’s main analogues with a special focus on a newly discovered naturally occurring analogue with intriguing biological properties and potential health benefits, 23-hydroxy ursolic acid.
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spelling pubmed-83889882021-08-27 Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits Nguyen, Huynh Nga Ullevig, Sarah L. Short, John D. Wang, Luxi Ahn, Yong Joo Asmis, Reto Antioxidants (Basel) Review Ursolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a number of traditional Chinese medicinal plants. UA has a broad range of biological activities and numerous potential health benefits. In this review, we summarize the current data on the bioavailability and pharmacokinetics of UA and review the literature on the biological activities of UA and its closest analogues in the context of inflammation, metabolic diseases, including liver and kidney diseases, obesity and diabetes, cardiovascular diseases, cancer, and neurological disorders. We end with a brief overview of UA’s main analogues with a special focus on a newly discovered naturally occurring analogue with intriguing biological properties and potential health benefits, 23-hydroxy ursolic acid. MDPI 2021-07-21 /pmc/articles/PMC8388988/ /pubmed/34439409 http://dx.doi.org/10.3390/antiox10081161 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nguyen, Huynh Nga
Ullevig, Sarah L.
Short, John D.
Wang, Luxi
Ahn, Yong Joo
Asmis, Reto
Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
title Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
title_full Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
title_fullStr Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
title_full_unstemmed Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
title_short Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
title_sort ursolic acid and related analogues: triterpenoids with broad health benefits
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388988/
https://www.ncbi.nlm.nih.gov/pubmed/34439409
http://dx.doi.org/10.3390/antiox10081161
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