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Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits
Ursolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a number of traditional Chinese medicinal plants. UA has a broad range of biological activities and numerous potential health benefits. In this review, we summarize the current data on the bioavailability...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388988/ https://www.ncbi.nlm.nih.gov/pubmed/34439409 http://dx.doi.org/10.3390/antiox10081161 |
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author | Nguyen, Huynh Nga Ullevig, Sarah L. Short, John D. Wang, Luxi Ahn, Yong Joo Asmis, Reto |
author_facet | Nguyen, Huynh Nga Ullevig, Sarah L. Short, John D. Wang, Luxi Ahn, Yong Joo Asmis, Reto |
author_sort | Nguyen, Huynh Nga |
collection | PubMed |
description | Ursolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a number of traditional Chinese medicinal plants. UA has a broad range of biological activities and numerous potential health benefits. In this review, we summarize the current data on the bioavailability and pharmacokinetics of UA and review the literature on the biological activities of UA and its closest analogues in the context of inflammation, metabolic diseases, including liver and kidney diseases, obesity and diabetes, cardiovascular diseases, cancer, and neurological disorders. We end with a brief overview of UA’s main analogues with a special focus on a newly discovered naturally occurring analogue with intriguing biological properties and potential health benefits, 23-hydroxy ursolic acid. |
format | Online Article Text |
id | pubmed-8388988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83889882021-08-27 Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits Nguyen, Huynh Nga Ullevig, Sarah L. Short, John D. Wang, Luxi Ahn, Yong Joo Asmis, Reto Antioxidants (Basel) Review Ursolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a number of traditional Chinese medicinal plants. UA has a broad range of biological activities and numerous potential health benefits. In this review, we summarize the current data on the bioavailability and pharmacokinetics of UA and review the literature on the biological activities of UA and its closest analogues in the context of inflammation, metabolic diseases, including liver and kidney diseases, obesity and diabetes, cardiovascular diseases, cancer, and neurological disorders. We end with a brief overview of UA’s main analogues with a special focus on a newly discovered naturally occurring analogue with intriguing biological properties and potential health benefits, 23-hydroxy ursolic acid. MDPI 2021-07-21 /pmc/articles/PMC8388988/ /pubmed/34439409 http://dx.doi.org/10.3390/antiox10081161 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nguyen, Huynh Nga Ullevig, Sarah L. Short, John D. Wang, Luxi Ahn, Yong Joo Asmis, Reto Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits |
title | Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits |
title_full | Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits |
title_fullStr | Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits |
title_full_unstemmed | Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits |
title_short | Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits |
title_sort | ursolic acid and related analogues: triterpenoids with broad health benefits |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388988/ https://www.ncbi.nlm.nih.gov/pubmed/34439409 http://dx.doi.org/10.3390/antiox10081161 |
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