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Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities
The synthesis of new compounds with antimicrobial and antiviral properties is a central objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole compounds have remarkable biological properties, such as antimicrobial, antiviral, antitumor, analgesic, anti-inflammatory, anti...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389006/ https://www.ncbi.nlm.nih.gov/pubmed/34439052 http://dx.doi.org/10.3390/antibiotics10081002 |
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author | Marinescu, Maria |
author_facet | Marinescu, Maria |
author_sort | Marinescu, Maria |
collection | PubMed |
description | The synthesis of new compounds with antimicrobial and antiviral properties is a central objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole compounds have remarkable biological properties, such as antimicrobial, antiviral, antitumor, analgesic, anti-inflammatory, anti-Alzheimer’s, antiulcer, antidiabetic. Moreover, recent literature mentions the syntheses and antimicrobial properties of some benzimidazole–pyrazole hybrids, as well as other biological properties thereof. In this review, we aim to review the methods of synthesis of these hybrids, the antimicrobial activities of the compounds, their correlation with various groups present on the molecule, as well as their pharmaceutical properties. |
format | Online Article Text |
id | pubmed-8389006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83890062021-08-27 Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities Marinescu, Maria Antibiotics (Basel) Review The synthesis of new compounds with antimicrobial and antiviral properties is a central objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole compounds have remarkable biological properties, such as antimicrobial, antiviral, antitumor, analgesic, anti-inflammatory, anti-Alzheimer’s, antiulcer, antidiabetic. Moreover, recent literature mentions the syntheses and antimicrobial properties of some benzimidazole–pyrazole hybrids, as well as other biological properties thereof. In this review, we aim to review the methods of synthesis of these hybrids, the antimicrobial activities of the compounds, their correlation with various groups present on the molecule, as well as their pharmaceutical properties. MDPI 2021-08-19 /pmc/articles/PMC8389006/ /pubmed/34439052 http://dx.doi.org/10.3390/antibiotics10081002 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Marinescu, Maria Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities |
title | Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities |
title_full | Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities |
title_fullStr | Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities |
title_full_unstemmed | Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities |
title_short | Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities |
title_sort | synthesis of antimicrobial benzimidazole–pyrazole compounds and their biological activities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389006/ https://www.ncbi.nlm.nih.gov/pubmed/34439052 http://dx.doi.org/10.3390/antibiotics10081002 |
work_keys_str_mv | AT marinescumaria synthesisofantimicrobialbenzimidazolepyrazolecompoundsandtheirbiologicalactivities |