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Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities

The synthesis of new compounds with antimicrobial and antiviral properties is a central objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole compounds have remarkable biological properties, such as antimicrobial, antiviral, antitumor, analgesic, anti-inflammatory, anti...

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Detalles Bibliográficos
Autor principal: Marinescu, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389006/
https://www.ncbi.nlm.nih.gov/pubmed/34439052
http://dx.doi.org/10.3390/antibiotics10081002
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author Marinescu, Maria
author_facet Marinescu, Maria
author_sort Marinescu, Maria
collection PubMed
description The synthesis of new compounds with antimicrobial and antiviral properties is a central objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole compounds have remarkable biological properties, such as antimicrobial, antiviral, antitumor, analgesic, anti-inflammatory, anti-Alzheimer’s, antiulcer, antidiabetic. Moreover, recent literature mentions the syntheses and antimicrobial properties of some benzimidazole–pyrazole hybrids, as well as other biological properties thereof. In this review, we aim to review the methods of synthesis of these hybrids, the antimicrobial activities of the compounds, their correlation with various groups present on the molecule, as well as their pharmaceutical properties.
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spelling pubmed-83890062021-08-27 Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities Marinescu, Maria Antibiotics (Basel) Review The synthesis of new compounds with antimicrobial and antiviral properties is a central objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole compounds have remarkable biological properties, such as antimicrobial, antiviral, antitumor, analgesic, anti-inflammatory, anti-Alzheimer’s, antiulcer, antidiabetic. Moreover, recent literature mentions the syntheses and antimicrobial properties of some benzimidazole–pyrazole hybrids, as well as other biological properties thereof. In this review, we aim to review the methods of synthesis of these hybrids, the antimicrobial activities of the compounds, their correlation with various groups present on the molecule, as well as their pharmaceutical properties. MDPI 2021-08-19 /pmc/articles/PMC8389006/ /pubmed/34439052 http://dx.doi.org/10.3390/antibiotics10081002 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Marinescu, Maria
Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities
title Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities
title_full Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities
title_fullStr Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities
title_full_unstemmed Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities
title_short Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities
title_sort synthesis of antimicrobial benzimidazole–pyrazole compounds and their biological activities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389006/
https://www.ncbi.nlm.nih.gov/pubmed/34439052
http://dx.doi.org/10.3390/antibiotics10081002
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