Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production

Fisetin has numerous therapeutic properties, such as anti-inflammatory, antioxidative, and anticancer effects. However, the mechanism by which fisetin inhibits NLRP3 inflammasome remains unclear. In this study, we observed that fisetin bound to TLR4 and occluded the hydrophobic pocket of MD2, which...

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Detalles Bibliográficos
Autores principales: Molagoda, Ilandarage Menu Neelaka, Athapaththu, Athapaththu Mudiyanselage Gihan Kavinda, Choi, Yung Hyun, Park, Cheol, Jin, Cheng-Yung, Kang, Chang-Hee, Lee, Mi-Hwa, Kim, Gi-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389007/
https://www.ncbi.nlm.nih.gov/pubmed/34439462
http://dx.doi.org/10.3390/antiox10081215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389007/
https://www.ncbi.nlm.nih.gov/pubmed/34439462
http://dx.doi.org/10.3390/antiox10081215

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