Cargando…

The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields

Superparamagnetic magnetite nanoparticles (MNPs) with excellent biocompatibility and negligible toxicity were prepared by solvothermal method and stabilized by widely used and biocompatible polymer poly(ethylene glycol) PEG-4000 Da. The unique properties of the synthesized MNPs enable them to host t...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandić, Lucija, Sadžak, Anja, Erceg, Ina, Baranović, Goran, Šegota, Suzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389039/
https://www.ncbi.nlm.nih.gov/pubmed/34439459
http://dx.doi.org/10.3390/antiox10081212
_version_ 1783742773200945152
author Mandić, Lucija
Sadžak, Anja
Erceg, Ina
Baranović, Goran
Šegota, Suzana
author_facet Mandić, Lucija
Sadžak, Anja
Erceg, Ina
Baranović, Goran
Šegota, Suzana
author_sort Mandić, Lucija
collection PubMed
description Superparamagnetic magnetite nanoparticles (MNPs) with excellent biocompatibility and negligible toxicity were prepared by solvothermal method and stabilized by widely used and biocompatible polymer poly(ethylene glycol) PEG-4000 Da. The unique properties of the synthesized MNPs enable them to host the unstable and water-insoluble quercetin as well as deliver and localize quercetin directly to the desired site. The chemical and physical properties were validated by X-ray powder diffraction (XRPD), field emission scanning electron microscopy (FE–SEM), atomic force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, FTIR spectroscopy and dynamic light scattering (DLS). The kinetics of in vitro quercetin release from MNPs followed by UV/VIS spectroscopy was controlled by employing combined stationary and alternating magnetic fields. The obtained results have shown an increased response of quercetin from superparamagnetic MNPs under a lower stationary magnetic field and s higher frequency of alternating magnetic field. The achieved findings suggested that we designed promising targeted quercetin delivery with fine-tuning drug release from magnetic MNPs.
format Online
Article
Text
id pubmed-8389039
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83890392021-08-27 The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields Mandić, Lucija Sadžak, Anja Erceg, Ina Baranović, Goran Šegota, Suzana Antioxidants (Basel) Article Superparamagnetic magnetite nanoparticles (MNPs) with excellent biocompatibility and negligible toxicity were prepared by solvothermal method and stabilized by widely used and biocompatible polymer poly(ethylene glycol) PEG-4000 Da. The unique properties of the synthesized MNPs enable them to host the unstable and water-insoluble quercetin as well as deliver and localize quercetin directly to the desired site. The chemical and physical properties were validated by X-ray powder diffraction (XRPD), field emission scanning electron microscopy (FE–SEM), atomic force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, FTIR spectroscopy and dynamic light scattering (DLS). The kinetics of in vitro quercetin release from MNPs followed by UV/VIS spectroscopy was controlled by employing combined stationary and alternating magnetic fields. The obtained results have shown an increased response of quercetin from superparamagnetic MNPs under a lower stationary magnetic field and s higher frequency of alternating magnetic field. The achieved findings suggested that we designed promising targeted quercetin delivery with fine-tuning drug release from magnetic MNPs. MDPI 2021-07-28 /pmc/articles/PMC8389039/ /pubmed/34439459 http://dx.doi.org/10.3390/antiox10081212 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mandić, Lucija
Sadžak, Anja
Erceg, Ina
Baranović, Goran
Šegota, Suzana
The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields
title The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields
title_full The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields
title_fullStr The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields
title_full_unstemmed The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields
title_short The Fine-Tuned Release of Antioxidant from Superparamagnetic Nanocarriers under the Combination of Stationary and Alternating Magnetic Fields
title_sort fine-tuned release of antioxidant from superparamagnetic nanocarriers under the combination of stationary and alternating magnetic fields
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389039/
https://www.ncbi.nlm.nih.gov/pubmed/34439459
http://dx.doi.org/10.3390/antiox10081212
work_keys_str_mv AT mandiclucija thefinetunedreleaseofantioxidantfromsuperparamagneticnanocarriersunderthecombinationofstationaryandalternatingmagneticfields
AT sadzakanja thefinetunedreleaseofantioxidantfromsuperparamagneticnanocarriersunderthecombinationofstationaryandalternatingmagneticfields
AT ercegina thefinetunedreleaseofantioxidantfromsuperparamagneticnanocarriersunderthecombinationofstationaryandalternatingmagneticfields
AT baranovicgoran thefinetunedreleaseofantioxidantfromsuperparamagneticnanocarriersunderthecombinationofstationaryandalternatingmagneticfields
AT segotasuzana thefinetunedreleaseofantioxidantfromsuperparamagneticnanocarriersunderthecombinationofstationaryandalternatingmagneticfields
AT mandiclucija finetunedreleaseofantioxidantfromsuperparamagneticnanocarriersunderthecombinationofstationaryandalternatingmagneticfields
AT sadzakanja finetunedreleaseofantioxidantfromsuperparamagneticnanocarriersunderthecombinationofstationaryandalternatingmagneticfields
AT ercegina finetunedreleaseofantioxidantfromsuperparamagneticnanocarriersunderthecombinationofstationaryandalternatingmagneticfields
AT baranovicgoran finetunedreleaseofantioxidantfromsuperparamagneticnanocarriersunderthecombinationofstationaryandalternatingmagneticfields
AT segotasuzana finetunedreleaseofantioxidantfromsuperparamagneticnanocarriersunderthecombinationofstationaryandalternatingmagneticfields