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TCA Cycle and Its Relationship with Clavulanic Acid Production: A Further Interpretation by Using a Reduced Genome-Scale Metabolic Model of Streptomyces clavuligerus

Streptomyces clavuligerus (S. clavuligerus) has been widely studied for its ability to produce clavulanic acid (CA), a potent inhibitor of β-lactamase enzymes. In this study, S. clavuligerus cultivated in 2D rocking bioreactor in fed-batch operation produced CA at comparable rates to those observed...

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Detalles Bibliográficos
Autores principales:	Ramirez-Malule, Howard, López-Agudelo, Víctor A., Gómez-Ríos, David, Ochoa, Silvia, Ríos-Estepa, Rigoberto, Junne, Stefan, Neubauer, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389198/ https://www.ncbi.nlm.nih.gov/pubmed/34436106 http://dx.doi.org/10.3390/bioengineering8080103

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