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Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review

Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory...

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Autores principales: Sharma, Meenakshi, Dhaliwal, Inderpreet, Rana, Kusum, Delta, Anil Kumar, Kaushik, Prashant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389218/
https://www.ncbi.nlm.nih.gov/pubmed/34439539
http://dx.doi.org/10.3390/antiox10081291
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author Sharma, Meenakshi
Dhaliwal, Inderpreet
Rana, Kusum
Delta, Anil Kumar
Kaushik, Prashant
author_facet Sharma, Meenakshi
Dhaliwal, Inderpreet
Rana, Kusum
Delta, Anil Kumar
Kaushik, Prashant
author_sort Sharma, Meenakshi
collection PubMed
description Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. With these pharmacological activities, D. stramonium is potentially used to treat numerous human diseases, including ulcers, inflammation, wounds, rheumatism, gout, bruises and swellings, sciatica, fever, toothache, asthma, and bronchitis. The primary phytochemicals investigation on plant extract of Datura showed alkaloids, carbohydrates, cardiac glycosides, tannins, flavonoids, amino acids, and phenolic compounds. It also contains toxic tropane alkaloids, including atropine, scopolamine, and hyoscamine. Although some studies on D. stramonium have reported potential pharmacological effects, information about the toxicity remains almost uncertain. Moreover, the frequent abuse of D. stramonium for recreational purposes has led to toxic syndromes. Therefore, it becomes necessary to be aware of the toxic aspects and the potential risks accompanying its use. The present review aims to summarize the phytochemical composition and pharmacological and toxicological aspects of the plant Datura.
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spelling pubmed-83892182021-08-27 Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review Sharma, Meenakshi Dhaliwal, Inderpreet Rana, Kusum Delta, Anil Kumar Kaushik, Prashant Antioxidants (Basel) Review Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. With these pharmacological activities, D. stramonium is potentially used to treat numerous human diseases, including ulcers, inflammation, wounds, rheumatism, gout, bruises and swellings, sciatica, fever, toothache, asthma, and bronchitis. The primary phytochemicals investigation on plant extract of Datura showed alkaloids, carbohydrates, cardiac glycosides, tannins, flavonoids, amino acids, and phenolic compounds. It also contains toxic tropane alkaloids, including atropine, scopolamine, and hyoscamine. Although some studies on D. stramonium have reported potential pharmacological effects, information about the toxicity remains almost uncertain. Moreover, the frequent abuse of D. stramonium for recreational purposes has led to toxic syndromes. Therefore, it becomes necessary to be aware of the toxic aspects and the potential risks accompanying its use. The present review aims to summarize the phytochemical composition and pharmacological and toxicological aspects of the plant Datura. MDPI 2021-08-15 /pmc/articles/PMC8389218/ /pubmed/34439539 http://dx.doi.org/10.3390/antiox10081291 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sharma, Meenakshi
Dhaliwal, Inderpreet
Rana, Kusum
Delta, Anil Kumar
Kaushik, Prashant
Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review
title Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review
title_full Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review
title_fullStr Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review
title_full_unstemmed Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review
title_short Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review
title_sort phytochemistry, pharmacology, and toxicology of datura species—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389218/
https://www.ncbi.nlm.nih.gov/pubmed/34439539
http://dx.doi.org/10.3390/antiox10081291
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