Cargando…
Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review
Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389218/ https://www.ncbi.nlm.nih.gov/pubmed/34439539 http://dx.doi.org/10.3390/antiox10081291 |
_version_ | 1783742809282445312 |
---|---|
author | Sharma, Meenakshi Dhaliwal, Inderpreet Rana, Kusum Delta, Anil Kumar Kaushik, Prashant |
author_facet | Sharma, Meenakshi Dhaliwal, Inderpreet Rana, Kusum Delta, Anil Kumar Kaushik, Prashant |
author_sort | Sharma, Meenakshi |
collection | PubMed |
description | Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. With these pharmacological activities, D. stramonium is potentially used to treat numerous human diseases, including ulcers, inflammation, wounds, rheumatism, gout, bruises and swellings, sciatica, fever, toothache, asthma, and bronchitis. The primary phytochemicals investigation on plant extract of Datura showed alkaloids, carbohydrates, cardiac glycosides, tannins, flavonoids, amino acids, and phenolic compounds. It also contains toxic tropane alkaloids, including atropine, scopolamine, and hyoscamine. Although some studies on D. stramonium have reported potential pharmacological effects, information about the toxicity remains almost uncertain. Moreover, the frequent abuse of D. stramonium for recreational purposes has led to toxic syndromes. Therefore, it becomes necessary to be aware of the toxic aspects and the potential risks accompanying its use. The present review aims to summarize the phytochemical composition and pharmacological and toxicological aspects of the plant Datura. |
format | Online Article Text |
id | pubmed-8389218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83892182021-08-27 Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review Sharma, Meenakshi Dhaliwal, Inderpreet Rana, Kusum Delta, Anil Kumar Kaushik, Prashant Antioxidants (Basel) Review Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. With these pharmacological activities, D. stramonium is potentially used to treat numerous human diseases, including ulcers, inflammation, wounds, rheumatism, gout, bruises and swellings, sciatica, fever, toothache, asthma, and bronchitis. The primary phytochemicals investigation on plant extract of Datura showed alkaloids, carbohydrates, cardiac glycosides, tannins, flavonoids, amino acids, and phenolic compounds. It also contains toxic tropane alkaloids, including atropine, scopolamine, and hyoscamine. Although some studies on D. stramonium have reported potential pharmacological effects, information about the toxicity remains almost uncertain. Moreover, the frequent abuse of D. stramonium for recreational purposes has led to toxic syndromes. Therefore, it becomes necessary to be aware of the toxic aspects and the potential risks accompanying its use. The present review aims to summarize the phytochemical composition and pharmacological and toxicological aspects of the plant Datura. MDPI 2021-08-15 /pmc/articles/PMC8389218/ /pubmed/34439539 http://dx.doi.org/10.3390/antiox10081291 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sharma, Meenakshi Dhaliwal, Inderpreet Rana, Kusum Delta, Anil Kumar Kaushik, Prashant Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review |
title | Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review |
title_full | Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review |
title_fullStr | Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review |
title_full_unstemmed | Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review |
title_short | Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review |
title_sort | phytochemistry, pharmacology, and toxicology of datura species—a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389218/ https://www.ncbi.nlm.nih.gov/pubmed/34439539 http://dx.doi.org/10.3390/antiox10081291 |
work_keys_str_mv | AT sharmameenakshi phytochemistrypharmacologyandtoxicologyofdaturaspeciesareview AT dhaliwalinderpreet phytochemistrypharmacologyandtoxicologyofdaturaspeciesareview AT ranakusum phytochemistrypharmacologyandtoxicologyofdaturaspeciesareview AT deltaanilkumar phytochemistrypharmacologyandtoxicologyofdaturaspeciesareview AT kaushikprashant phytochemistrypharmacologyandtoxicologyofdaturaspeciesareview |