Cargando…

Kidney Protection with the Radical Scavenger α(1)-Microglobulin (A1M) during Peptide Receptor Radionuclide and Radioligand Therapy

α(1)-Microglobulin (A1M) is an antioxidant found in all vertebrates, including humans. It has enzymatic reductase activity and can scavenge radicals and bind free heme groups. Infused recombinant A1M accumulates in the kidneys and has therefore been successful in protecting kidney injuries in differ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kristiansson, Amanda, Örbom, Anders, Vilhelmsson Timmermand, Oskar, Ahlstedt, Jonas, Strand, Sven-Erik, Åkerström, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389303/ https://www.ncbi.nlm.nih.gov/pubmed/34439519 http://dx.doi.org/10.3390/antiox10081271

Ejemplares similares

(177)Lu-PSMA-617 Therapy in Mice, with or without the Antioxidant α(1)-Microglobulin (A1M), Including Kidney Damage Assessment Using (99m)Tc-MAG3 Imaging
por: Kristiansson, Amanda, et al.
Publicado: (2021)

Hematological Toxicity in Mice after High Activity Injections of (177)Lu-PSMA-617
por: Kristiansson, Amanda, et al.
Publicado: (2022)

Protection of Kidney Function with Human Antioxidation Protein α(1)-Microglobulin in a Mouse (177)Lu-DOTATATE Radiation Therapy Model
por: Kristiansson, Amanda, et al.
Publicado: (2019)

Human Anti-Oxidation Protein A1M—A Potential Kidney Protection Agent in Peptide Receptor Radionuclide Therapy
por: Ahlstedt, Jonas, et al.
Publicado: (2015)

A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen
por: Vilhelmsson Timmermand, Oskar, et al.
Publicado: (2021)

Recombinant α(1)-Microglobulin (rA1M) Protects against Hematopoietic and Renal Toxicity, Alone and in Combination with Amino Acids, in a (177)Lu-DOTATATE Mouse Radiation Model
por: Alattar, Abdul Ghani, et al.
Publicado: (2023)

Small-scale dosimetry for alpha particle (241)Am source cell irradiation and estimation of γ-H2AX foci distribution in prostate cancer cell line PC3
por: Mellhammar, Emma, et al.
Publicado: (2022)

Humanization, Radiolabeling and Biodistribution Studies of an IgG(1)-Type Antibody Targeting Uncomplexed PSA for Theranostic Applications
por: Strand, Joanna, et al.
Publicado: (2021)

Preclinical efficacy of hK2 targeted [(177)Lu]hu11B6 for prostate cancer theranostics
por: Timmermand, Oskar Vilhelmsson, et al.
Publicado: (2019)

Structure, Functions, and Physiological Roles of the Lipocalin α(1)-Microglobulin (A1M)
por: Bergwik, Jesper, et al.
Publicado: (2021)

Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies
por: Kalapotharakos, Grigorios, et al.
Publicado: (2019)

The heme and radical scavenger α(1)-microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage
por: Romantsik, Olga, et al.
Publicado: (2019)

Hemopexin and α(1)-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction
por: Youssef, Lina, et al.
Publicado: (2020)

Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a (111)In-radiolabelled monoclonal antibody, 11B6
por: Timmermand, Oskar Vilhelmsson, et al.
Publicado: (2014)

The Role of α(1)-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis—Therapeutic Opportunities in Hemolytic Conditions
por: Kristiansson, Amanda, et al.
Publicado: (2020)

rA1M-035, a Physicochemically Improved Human Recombinant α(1)-Microglobulin, Has Therapeutic Effects in Rhabdomyolysis-Induced Acute Kidney Injury
por: Åkerström, Bo, et al.
Publicado: (2019)

Expression, Purification and Initial Characterization of Functional α(1)-Microglobulin (A1M) in Nicotiana benthamiana
por: Carlsson, Magnus L. R., et al.
Publicado: (2020)

α(1)-Microglobulin (A1M) Protects Human Proximal Tubule Epithelial Cells from Heme-Induced Damage In Vitro
por: Kristiansson, Amanda, et al.
Publicado: (2020)

Binding of the human antioxidation protein α(1)-microglobulin (A1M) to heparin and heparan sulfate. Mapping of binding site, molecular and functional characterization, and co-localization in vivo and in vitro
por: Bergwik, Jesper, et al.
Publicado: (2021)

Characterization of heme binding to recombinant α(1)-microglobulin
por: Karnaukhova, Elena, et al.
Publicado: (2014)

Radioimmunotherapy of prostate cancer targeting human kallikrein-related peptidase 2
por: Vilhelmsson Timmermand, O., et al.
Publicado: (2016)

α(1)-Microglobulin Protects Against Bleeding-Induced Oxidative Damage in Knee Arthropathies
por: Larsson, Staffan, et al.
Publicado: (2018)

α(1)-Microglobulin Binds Illuminated Flavins and Has a Protective Effect Against Sublethal Riboflavin-Induced Damage in Retinal Epithelial Cells
por: Bergwik, Jesper, et al.
Publicado: (2020)

A1M/α(1)-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation
por: Cederlund, Martin, et al.
Publicado: (2015)

Pregnant alpha-1-microglobulin (A1M) knockout mice exhibit features of kidney and placental damage, hemodynamic changes and intrauterine growth restriction
por: Aleksenko, Larysa, et al.
Publicado: (2020)

Up-Regulation of A1M/α(1)-Microglobulin in Skin by Heme and Reactive Oxygen Species Gives Protection from Oxidative Damage
por: Olsson, Magnus G., et al.
Publicado: (2011)

Longitudinal changes in plasma hemopexin and alpha-1-microglobulin concentrations in women with and without clinical risk factors for pre-eclampsia
por: Murtoniemi, Katja, et al.
Publicado: (2019)

Novel tyrosinase inhibitory peptide with free radical scavenging ability
por: Shen, Zhiwei, et al.
Publicado: (2019)

Peptide Radioligands in Cancer Theranostics: Agonists and Antagonists
por: Nock, Berthold A., et al.
Publicado: (2023)

Ferryl Hemoglobin and Heme Induce A(1)-Microglobulin in Hemorrhaged Atherosclerotic Lesions with Inhibitory Function against Hemoglobin and Lipid Oxidation
por: Pethő, Dávid, et al.
Publicado: (2021)

Scavenging Effects of Dexrazoxane on Free Radicals
por: Junjing, Zhang, et al.
Publicado: (2010)

Evaluation of radical scavenging properties of shikonin
por: Yoshida, Lucia S., et al.
Publicado: (2014)

Is natural fraxin an overlooked radical scavenger?
por: Nam, Pham Cam, et al.
Publicado: (2021)

A1M/α(1)-Microglobulin Protects from Heme-Induced Placental and Renal Damage in a Pregnant Sheep Model of Preeclampsia
por: Wester-Rosenlöf, Lena, et al.
Publicado: (2014)

Hydroxyl Radical and Its Scavengers in Health and Disease
por: Lipinski, Boguslaw
Publicado: (2011)

Multiple free-radical scavenging capacity in serum
por: Oowada, Shigeru, et al.
Publicado: (2012)

Free radical scavengers in anaesthesiology and critical care
por: Hatwalne, Milind S
Publicado: (2012)

Free radical scavenging properties of pyrimidine derivatives
por: Bano, Tabassum, et al.
Publicado: (2012)

Free Radical Scavenging Properties of Annona squamosa
por: Vikas, Biba, et al.
Publicado: (2017)

Substituent Effects on the Radical Scavenging Activity of Isoflavonoid
por: Zheng, Yan-Zhen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_b1aaqqef7k0r174hd719gvgdoe