Early Cytokine-Induced Transient NOX2 Activity Is ER Stress-Dependent and Impacts β-Cell Function and Survival

In type 1 diabetes (T1D) development, proinflammatory cytokines (PIC) released by immune cells lead to increased reactive oxygen species (ROS) production in β-cells. Nonetheless, the temporality of the events triggered and the role of different ROS sources remain unclear. Isolated islets from C57BL/...

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Detalles Bibliográficos
Autores principales: Vilas-Boas, Eloisa A., Carlein, Christopher, Nalbach, Lisa, Almeida, Davidson C., Ampofo, Emmanuel, Carpinelli, Angelo R., Roma, Leticia P., Ortis, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389306/
https://www.ncbi.nlm.nih.gov/pubmed/34439552
http://dx.doi.org/10.3390/antiox10081305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389306/
https://www.ncbi.nlm.nih.gov/pubmed/34439552
http://dx.doi.org/10.3390/antiox10081305

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