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Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review
The current knowledge about the mechanisms of action of light-based treatments (chiefly photodynamic therapy and phototherapy) in skin diseases leans to the possible involvement of epigenetic and oxidative stress mechanisms. To better understand and exploit, to the fullest, these relatively safe and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389319/ https://www.ncbi.nlm.nih.gov/pubmed/34439557 http://dx.doi.org/10.3390/antiox10081310 |
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author | Borgia, Francesco Custurone, Paolo Peterle, Lucia Pioggia, Giovanni Guarneri, Fabrizio Gangemi, Sebastiano |
author_facet | Borgia, Francesco Custurone, Paolo Peterle, Lucia Pioggia, Giovanni Guarneri, Fabrizio Gangemi, Sebastiano |
author_sort | Borgia, Francesco |
collection | PubMed |
description | The current knowledge about the mechanisms of action of light-based treatments (chiefly photodynamic therapy and phototherapy) in skin diseases leans to the possible involvement of epigenetic and oxidative stress mechanisms. To better understand and exploit, to the fullest, these relatively safe and reproducible treatments, several studies have focused on miRNAs, small non-encoding RNAs (22–24 nucleotides), after light-based treatments. The current narrative review focused on 25 articles. A meta-analysis was not deemed appropriate. The results gather the most recurrent skin-related miRNAs up- or downregulated after light treatment. Five of these, miR-21, -29, -125, -145 and -155, are either the most consistently related to efficacy/resistance to treatment or identified as helpful diagnostic tools. A specific class of miRNAs (angioMIRs) requires further studies. Future treatments and imaging techniques could benefit greatly from the use of antagomirs as a possible co-adjuvant therapy along with light-based treatments. |
format | Online Article Text |
id | pubmed-8389319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83893192021-08-27 Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review Borgia, Francesco Custurone, Paolo Peterle, Lucia Pioggia, Giovanni Guarneri, Fabrizio Gangemi, Sebastiano Antioxidants (Basel) Review The current knowledge about the mechanisms of action of light-based treatments (chiefly photodynamic therapy and phototherapy) in skin diseases leans to the possible involvement of epigenetic and oxidative stress mechanisms. To better understand and exploit, to the fullest, these relatively safe and reproducible treatments, several studies have focused on miRNAs, small non-encoding RNAs (22–24 nucleotides), after light-based treatments. The current narrative review focused on 25 articles. A meta-analysis was not deemed appropriate. The results gather the most recurrent skin-related miRNAs up- or downregulated after light treatment. Five of these, miR-21, -29, -125, -145 and -155, are either the most consistently related to efficacy/resistance to treatment or identified as helpful diagnostic tools. A specific class of miRNAs (angioMIRs) requires further studies. Future treatments and imaging techniques could benefit greatly from the use of antagomirs as a possible co-adjuvant therapy along with light-based treatments. MDPI 2021-08-20 /pmc/articles/PMC8389319/ /pubmed/34439557 http://dx.doi.org/10.3390/antiox10081310 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Borgia, Francesco Custurone, Paolo Peterle, Lucia Pioggia, Giovanni Guarneri, Fabrizio Gangemi, Sebastiano Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review |
title | Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review |
title_full | Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review |
title_fullStr | Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review |
title_full_unstemmed | Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review |
title_short | Involvement of microRNAs as a Response to Phototherapy and Photodynamic Therapy: A Literature Review |
title_sort | involvement of micrornas as a response to phototherapy and photodynamic therapy: a literature review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389319/ https://www.ncbi.nlm.nih.gov/pubmed/34439557 http://dx.doi.org/10.3390/antiox10081310 |
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