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Decreased spasticity of Baishaoluoshi Decoction through the BDNF/TrKB-KCC2 pathway on poststroke spasticity rats

OBJECTIVE: K(+)–Cl(−) cotransporter-2 (KCC2), which primarily extrudes chloride in mature neurons, triggers hemiplegia limb spasticity after ischemic stroke by affecting neuronal excitability. Our previous study revealed that the Chinese herb Baishaoluoshi Decoction decreases hemiplegia limb spastic...

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Detalles Bibliográficos
Autores principales:	Xie, Le, Xie, Yao, Mao, Guo, Cao, Sijia, Fang, Rui, Zhou, Shen, Jiang, Junlin, Yao, Ting, Fan, Jianhu, Liu, Dong, Wu, Dahua, Ge, Jinwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Cellular, Molecular and Developmental Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389354/ https://www.ncbi.nlm.nih.gov/pubmed/34284448 http://dx.doi.org/10.1097/WNR.0000000000001709

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