Cargando…
The impact of age on genetic risk for common diseases
Inherited genetic variation contributes to individual risk for many complex diseases and is increasingly being used for predictive patient stratification. Previous work has shown that genetic factors are not equally relevant to human traits across age and other contexts, though the reasons for such...
Autores principales: | Jiang, Xilin, Holmes, Chris, McVean, Gil |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389405/ https://www.ncbi.nlm.nih.gov/pubmed/34437535 http://dx.doi.org/10.1371/journal.pgen.1009723 |
Ejemplares similares
-
Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk
por: Jiang, Xilin, et al.
Publicado: (2023) -
Topic modeling identifies novel genetic loci associated with multimorbidities in UK Biobank
por: Zhang, Yidong, et al.
Publicado: (2023) -
Differential confounding of rare and common variants in spatially structured populations
por: Mathieson, Iain, et al.
Publicado: (2012) -
Demography and the Age of Rare Variants
por: Mathieson, Iain, et al.
Publicado: (2014) -
Optimal strategies for learning multi-ancestry polygenic scores vary across traits
por: Lehmann, Brieuc, et al.
Publicado: (2023)