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Multiple states in ongoing neural activity in the rat visual cortex
The brain continuously produces internal activity in the absence of afferently salient sensory input. Spontaneous neural activity is intrinsically defined by circuit structures and associated with the mode of information processing and behavioral responses. However, the spatiotemporal dynamics of sp...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389421/ https://www.ncbi.nlm.nih.gov/pubmed/34437630 http://dx.doi.org/10.1371/journal.pone.0256791 |
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author | Konno, Daichi Nishimoto, Shinji Suzuki, Takafumi Ikegaya, Yuji Matsumoto, Nobuyoshi |
author_facet | Konno, Daichi Nishimoto, Shinji Suzuki, Takafumi Ikegaya, Yuji Matsumoto, Nobuyoshi |
author_sort | Konno, Daichi |
collection | PubMed |
description | The brain continuously produces internal activity in the absence of afferently salient sensory input. Spontaneous neural activity is intrinsically defined by circuit structures and associated with the mode of information processing and behavioral responses. However, the spatiotemporal dynamics of spontaneous activity in the visual cortices of behaving animals remain almost elusive. Using a custom-made electrode array, we recorded 32-site electrocorticograms in the primary and secondary visual cortex of freely behaving rats and determined the propagation patterns of spontaneous neural activity. Nonlinear dimensionality reduction and unsupervised clustering revealed multiple discrete states of the activity patterns. The activity remained stable in one state and suddenly jumped to another state. The diversity and dynamics of the internally switching cortical states would imply flexibility of neural responses to various external inputs. |
format | Online Article Text |
id | pubmed-8389421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83894212021-08-27 Multiple states in ongoing neural activity in the rat visual cortex Konno, Daichi Nishimoto, Shinji Suzuki, Takafumi Ikegaya, Yuji Matsumoto, Nobuyoshi PLoS One Research Article The brain continuously produces internal activity in the absence of afferently salient sensory input. Spontaneous neural activity is intrinsically defined by circuit structures and associated with the mode of information processing and behavioral responses. However, the spatiotemporal dynamics of spontaneous activity in the visual cortices of behaving animals remain almost elusive. Using a custom-made electrode array, we recorded 32-site electrocorticograms in the primary and secondary visual cortex of freely behaving rats and determined the propagation patterns of spontaneous neural activity. Nonlinear dimensionality reduction and unsupervised clustering revealed multiple discrete states of the activity patterns. The activity remained stable in one state and suddenly jumped to another state. The diversity and dynamics of the internally switching cortical states would imply flexibility of neural responses to various external inputs. Public Library of Science 2021-08-26 /pmc/articles/PMC8389421/ /pubmed/34437630 http://dx.doi.org/10.1371/journal.pone.0256791 Text en © 2021 Konno et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Konno, Daichi Nishimoto, Shinji Suzuki, Takafumi Ikegaya, Yuji Matsumoto, Nobuyoshi Multiple states in ongoing neural activity in the rat visual cortex |
title | Multiple states in ongoing neural activity in the rat visual cortex |
title_full | Multiple states in ongoing neural activity in the rat visual cortex |
title_fullStr | Multiple states in ongoing neural activity in the rat visual cortex |
title_full_unstemmed | Multiple states in ongoing neural activity in the rat visual cortex |
title_short | Multiple states in ongoing neural activity in the rat visual cortex |
title_sort | multiple states in ongoing neural activity in the rat visual cortex |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389421/ https://www.ncbi.nlm.nih.gov/pubmed/34437630 http://dx.doi.org/10.1371/journal.pone.0256791 |
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