SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon

Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral infection. Resultantly, many viruses have evolved mechanisms in which to evade the IFN-I response. Here we tested the impact of expression of 27 different SARS-CoV-2 genes in relation to their effect on...

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Detalles Bibliográficos
Autores principales: Shemesh, Maya, Aktepe, Turgut E., Deerain, Joshua M., McAuley, Julie L., Audsley, Michelle D., David, Cassandra T., Purcell, Damian F. J., Urin, Victoria, Hartmann, Rune, Moseley, Gregory W., Mackenzie, Jason M., Schreiber, Gideon, Harari, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389490/
https://www.ncbi.nlm.nih.gov/pubmed/34437657
http://dx.doi.org/10.1371/journal.ppat.1009800

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