Cargando…

Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood–brain barrier during kainic acid-induced brain damage

Rufinamide (RUF) is a structurally unique anti-epileptic drug, but its protective mechanism against brain injury remains unclear. In the present study, we validated how the RUF protected mice with kainic acid (KA)-induced neuronal damage. To achieve that, a mouse epilepsy model was established by KA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Huaxu, He, Bin, Han, Xu, Yan, Ting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	De Gruyter 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389504/ https://www.ncbi.nlm.nih.gov/pubmed/34514163 http://dx.doi.org/10.1515/biol-2021-0090

Ejemplares similares

Weisheng-Tang Ameliorates Acute Ischemic Brain Damage in Mice by Maintaining Blood-Brain Barrier Integrity
por: Kim, Min Jae, et al.
Publicado: (2019)

Update on rufinamide in childhood epilepsy
por: Coppola, Giangennaro
Publicado: (2011)

Brain endothelial LRP1 maintains blood–brain barrier integrity
por: Storck, Steffen E., et al.
Publicado: (2021)

The Efficacy and Tolerability of Rufinamide in Intractable Pediatric Epilepsy
por: Kim, Jae Yeon, et al.
Publicado: (2012)

Mitochondrial DNA variation of the ruffed grouse (Bonasa umbellus)
por: Honeycutt, Rodney L., et al.
Publicado: (2019)

Celecoxib Alleviates Radiation-Induced Brain Injury in Rats by Maintaining the Integrity of Blood-Brain Barrier
por: Xu, Xiaoting, et al.
Publicado: (2021)

Rufinamide-Loaded Chitosan Nanoparticles in Xyloglucan-Based Thermoresponsive In Situ Gel for Direct Nose to Brain Delivery
por: Dalvi, Avantika, et al.
Publicado: (2021)

Changes in the Blood-Brain Barrier Function Are Associated With Hippocampal Neuron Death in a Kainic Acid Mouse Model of Epilepsy
por: Yan, Bing Chun, et al.
Publicado: (2018)

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity
por: Yao, Yao, et al.
Publicado: (2014)

The Ketogenic Diet Suppresses the Cathepsin E Expression Induced by Kainic Acid in the Rat Brain
por: Jeong, Hyun Jeong, et al.
Publicado: (2010)

Book Reviews: Jakob Ruf: Leben, Werk und Studien
por: Spinks, Jennifer
Publicado: (2010)

Insights into Substrate Recognition by the Unusual Nitrating Enzyme RufO
por: Dratch, Benjamin D., et al.
Publicado: (2023)

Design and evaluation of rufinamide nanocrystals loaded thermoresponsive nasal in situ gelling system for improved drug distribution to brain
por: Dalvi, Avantika, et al.
Publicado: (2022)

The Potential Roles of Blood–Brain Barrier and Blood–Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis
por: McCabe, Shannon Morgan, et al.
Publicado: (2021)

MicroRNA-29b Suppresses Inflammation and Protects Blood-Brain Barrier Integrity in Ischemic Stroke
por: Ma, Xiaoqing, et al.
Publicado: (2022)

Alleviation of Kainic Acid-Induced Brain Barrier Dysfunction by 4-O-Methylhonokiol in In Vitro and In Vivo Models
por: Han, Jin-Yi, et al.
Publicado: (2015)

Update on the management of Lennox-Gastaut syndrome with a focus on rufinamide
por: Stafstrom, Carl E
Publicado: (2009)

Stroke-induced damage on the blood–brain barrier
por: Xue, Song, et al.
Publicado: (2023)

Landscape effects on the contemporary genetic structure of Ruffed Grouse (Bonasa umbellus) populations
por: Jensen, Ashley M., et al.
Publicado: (2019)

Angiostrongylus cantonensis in a Red Ruffed Lemur at a Zoo, Louisiana, USA
por: Rizor, Jessica, et al.
Publicado: (2022)

Role of rufinamide in the management of Lennox-Gastaut syndrome (childhood epileptic encephalopathy)
por: Kluger, Gerhard, et al.
Publicado: (2007)

Onset of action and seizure control in Lennox-Gaustaut syndrome: focus on rufinamide
por: Saneto, Russell P, et al.
Publicado: (2009)

Adjunctive Rufinamide in Children with Lennox-Gastaut Syndrome: A Literature Review
por: Balagura, Ganna, et al.
Publicado: (2020)

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity
por: Miner, Jonathan J., et al.
Publicado: (2015)

C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity
por: Perez-Ternero, Cristina, et al.
Publicado: (2022)

PRDX6 controls multiple sclerosis by suppressing inflammation and blood brain barrier disruption
por: Yun, Hyung-Mun, et al.
Publicado: (2015)

The blood–brain barrier in systemic infection and inflammation
por: Galea, Ian
Publicado: (2021)

Sortilins in the blood-brain barrier: impact on barrier integrity
por: Toth, Andrea E., et al.
Publicado: (2022)

Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice
por: Shi, Xianqing, et al.
Publicado: (2017)

Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2
por: Xu, Lingling, et al.
Publicado: (2022)

Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model
por: Mao, Xiao W., et al.
Publicado: (2020)

Neuro-Axonal Damage and Alteration of Blood–Brain Barrier Integrity in COVID-19 Patients
por: Zingaropoli, Maria Antonella, et al.
Publicado: (2022)

Treating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide
por: Gresham, Jessica, et al.
Publicado: (2010)

Development and validation of a stability indicating RP-HPLC method for the determination of Rufinamide
por: Sai Pavan Kumar, B., et al.
Publicado: (2013)

Blood-Brain Barrier Integrity and Breast Cancer Metastasis to the Brain
por: Arshad, Farheen, et al.
Publicado: (2010)

Ribonuclease-1 treatment after traumatic brain injury preserves blood–brain barrier integrity and delays secondary brain damage in mice
por: Krämer, Tobias J., et al.
Publicado: (2022)

Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway
por: Hsieh, Ting-Yang, et al.
Publicado: (2022)

SARS-COV2 Alters Blood Brain Barrier Integrity Contributing to Neuro-Inflammation
por: Reynolds, Jessica. L., et al.
Publicado: (2021)

Fetal Brain Transplantation in Kainic Acid Lesioned Caudate Nucleus of Adult Rats
por: Tandon, P. N., et al.
Publicado: (1992)

A Prosaposin-Derived Peptide Alleviates Kainic Acid-Induced Brain Injury
por: Nabeka, Hiroaki, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6og451hr0mpatl50vhttb1d6aq