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Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review
Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA and RA involves multiple tissues within the joint...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389545/ https://www.ncbi.nlm.nih.gov/pubmed/34440106 http://dx.doi.org/10.3390/biomedicines9080902 |
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author | Wijesinghe, Susanne N. Lindsay, Mark A. Jones, Simon W. |
author_facet | Wijesinghe, Susanne N. Lindsay, Mark A. Jones, Simon W. |
author_sort | Wijesinghe, Susanne N. |
collection | PubMed |
description | Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA and RA involves multiple tissues within the joint, including the synovial joint lining and the bone, as well as the articular cartilage in OA. In this review, we discuss the potential for the development of oligonucleotide therapies for these disorders by examining the evidence that oligonucleotides can modulate the key cellular pathways that drive the pathology of the inflammatory diseased joint pathology, as well as evidence in preclinical in vivo models that oligonucleotides can modify disease progression. |
format | Online Article Text |
id | pubmed-8389545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83895452021-08-27 Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review Wijesinghe, Susanne N. Lindsay, Mark A. Jones, Simon W. Biomedicines Review Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA and RA involves multiple tissues within the joint, including the synovial joint lining and the bone, as well as the articular cartilage in OA. In this review, we discuss the potential for the development of oligonucleotide therapies for these disorders by examining the evidence that oligonucleotides can modulate the key cellular pathways that drive the pathology of the inflammatory diseased joint pathology, as well as evidence in preclinical in vivo models that oligonucleotides can modify disease progression. MDPI 2021-07-27 /pmc/articles/PMC8389545/ /pubmed/34440106 http://dx.doi.org/10.3390/biomedicines9080902 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wijesinghe, Susanne N. Lindsay, Mark A. Jones, Simon W. Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review |
title | Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review |
title_full | Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review |
title_fullStr | Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review |
title_full_unstemmed | Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review |
title_short | Oligonucleotide Therapies in the Treatment of Arthritis: A Narrative Review |
title_sort | oligonucleotide therapies in the treatment of arthritis: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389545/ https://www.ncbi.nlm.nih.gov/pubmed/34440106 http://dx.doi.org/10.3390/biomedicines9080902 |
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