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The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease
The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) o...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389558/ https://www.ncbi.nlm.nih.gov/pubmed/34440065 http://dx.doi.org/10.3390/biomedicines9080862 |
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author | Urpi-Sarda, Mireia Casas, Rosa Sacanella, Emilio Corella, Dolores Andrés-Lacueva, Cristina Llorach, Rafael Garrabou, Gloria Cardellach, Francesc Sala-Vila, Aleix Ros, Emilio Ruiz-Canela, Miguel Fitó, Montserrat Salas-Salvadó, Jordi Estruch, Ramon |
author_facet | Urpi-Sarda, Mireia Casas, Rosa Sacanella, Emilio Corella, Dolores Andrés-Lacueva, Cristina Llorach, Rafael Garrabou, Gloria Cardellach, Francesc Sala-Vila, Aleix Ros, Emilio Ruiz-Canela, Miguel Fitó, Montserrat Salas-Salvadó, Jordi Estruch, Ramon |
author_sort | Urpi-Sarda, Mireia |
collection | PubMed |
description | The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p < 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p < 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk. |
format | Online Article Text |
id | pubmed-8389558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83895582021-08-27 The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease Urpi-Sarda, Mireia Casas, Rosa Sacanella, Emilio Corella, Dolores Andrés-Lacueva, Cristina Llorach, Rafael Garrabou, Gloria Cardellach, Francesc Sala-Vila, Aleix Ros, Emilio Ruiz-Canela, Miguel Fitó, Montserrat Salas-Salvadó, Jordi Estruch, Ramon Biomedicines Article The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p < 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p < 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk. MDPI 2021-07-22 /pmc/articles/PMC8389558/ /pubmed/34440065 http://dx.doi.org/10.3390/biomedicines9080862 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Urpi-Sarda, Mireia Casas, Rosa Sacanella, Emilio Corella, Dolores Andrés-Lacueva, Cristina Llorach, Rafael Garrabou, Gloria Cardellach, Francesc Sala-Vila, Aleix Ros, Emilio Ruiz-Canela, Miguel Fitó, Montserrat Salas-Salvadó, Jordi Estruch, Ramon The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease |
title | The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease |
title_full | The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease |
title_fullStr | The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease |
title_full_unstemmed | The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease |
title_short | The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease |
title_sort | 3-year effect of the mediterranean diet intervention on inflammatory biomarkers related to cardiovascular disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389558/ https://www.ncbi.nlm.nih.gov/pubmed/34440065 http://dx.doi.org/10.3390/biomedicines9080862 |
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