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The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease

The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) o...

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Autores principales: Urpi-Sarda, Mireia, Casas, Rosa, Sacanella, Emilio, Corella, Dolores, Andrés-Lacueva, Cristina, Llorach, Rafael, Garrabou, Gloria, Cardellach, Francesc, Sala-Vila, Aleix, Ros, Emilio, Ruiz-Canela, Miguel, Fitó, Montserrat, Salas-Salvadó, Jordi, Estruch, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389558/
https://www.ncbi.nlm.nih.gov/pubmed/34440065
http://dx.doi.org/10.3390/biomedicines9080862
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author Urpi-Sarda, Mireia
Casas, Rosa
Sacanella, Emilio
Corella, Dolores
Andrés-Lacueva, Cristina
Llorach, Rafael
Garrabou, Gloria
Cardellach, Francesc
Sala-Vila, Aleix
Ros, Emilio
Ruiz-Canela, Miguel
Fitó, Montserrat
Salas-Salvadó, Jordi
Estruch, Ramon
author_facet Urpi-Sarda, Mireia
Casas, Rosa
Sacanella, Emilio
Corella, Dolores
Andrés-Lacueva, Cristina
Llorach, Rafael
Garrabou, Gloria
Cardellach, Francesc
Sala-Vila, Aleix
Ros, Emilio
Ruiz-Canela, Miguel
Fitó, Montserrat
Salas-Salvadó, Jordi
Estruch, Ramon
author_sort Urpi-Sarda, Mireia
collection PubMed
description The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p < 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p < 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk.
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spelling pubmed-83895582021-08-27 The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease Urpi-Sarda, Mireia Casas, Rosa Sacanella, Emilio Corella, Dolores Andrés-Lacueva, Cristina Llorach, Rafael Garrabou, Gloria Cardellach, Francesc Sala-Vila, Aleix Ros, Emilio Ruiz-Canela, Miguel Fitó, Montserrat Salas-Salvadó, Jordi Estruch, Ramon Biomedicines Article The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p < 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p < 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk. MDPI 2021-07-22 /pmc/articles/PMC8389558/ /pubmed/34440065 http://dx.doi.org/10.3390/biomedicines9080862 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Urpi-Sarda, Mireia
Casas, Rosa
Sacanella, Emilio
Corella, Dolores
Andrés-Lacueva, Cristina
Llorach, Rafael
Garrabou, Gloria
Cardellach, Francesc
Sala-Vila, Aleix
Ros, Emilio
Ruiz-Canela, Miguel
Fitó, Montserrat
Salas-Salvadó, Jordi
Estruch, Ramon
The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease
title The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease
title_full The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease
title_fullStr The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease
title_full_unstemmed The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease
title_short The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease
title_sort 3-year effect of the mediterranean diet intervention on inflammatory biomarkers related to cardiovascular disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389558/
https://www.ncbi.nlm.nih.gov/pubmed/34440065
http://dx.doi.org/10.3390/biomedicines9080862
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