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The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer

Alterations in the expression level of the MYC gene are often found in the cells of various malignant tumors. Overexpressed MYC has been shown to stimulate the main processes of oncogenesis: uncontrolled growth, unlimited cell divisions, avoidance of apoptosis and immune response, changes in cellula...

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Autores principales: Stasevich, Ekaterina Mikhailovna, Murashko, Matvey Mikhailovich, Zinevich, Lyudmila Sergeevna, Demin, Denis Eriksonovich, Schwartz, Anton Markovich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389562/
https://www.ncbi.nlm.nih.gov/pubmed/34440124
http://dx.doi.org/10.3390/biomedicines9080921
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author Stasevich, Ekaterina Mikhailovna
Murashko, Matvey Mikhailovich
Zinevich, Lyudmila Sergeevna
Demin, Denis Eriksonovich
Schwartz, Anton Markovich
author_facet Stasevich, Ekaterina Mikhailovna
Murashko, Matvey Mikhailovich
Zinevich, Lyudmila Sergeevna
Demin, Denis Eriksonovich
Schwartz, Anton Markovich
author_sort Stasevich, Ekaterina Mikhailovna
collection PubMed
description Alterations in the expression level of the MYC gene are often found in the cells of various malignant tumors. Overexpressed MYC has been shown to stimulate the main processes of oncogenesis: uncontrolled growth, unlimited cell divisions, avoidance of apoptosis and immune response, changes in cellular metabolism, genomic instability, metastasis, and angiogenesis. Thus, controlling the expression of MYC is considered as an approach for targeted cancer treatment. Since c-Myc is also a crucial regulator of many cellular processes in healthy cells, it is necessary to find ways for selective regulation of MYC expression in tumor cells. Many recent studies have demonstrated that non-coding RNAs play an important role in the regulation of the transcription and translation of this gene and some RNAs directly interact with the c-Myc protein, affecting its stability. In this review, we summarize current data on the regulation of MYC by various non-coding RNAs that can potentially be targeted in specific tumor types.
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spelling pubmed-83895622021-08-27 The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer Stasevich, Ekaterina Mikhailovna Murashko, Matvey Mikhailovich Zinevich, Lyudmila Sergeevna Demin, Denis Eriksonovich Schwartz, Anton Markovich Biomedicines Review Alterations in the expression level of the MYC gene are often found in the cells of various malignant tumors. Overexpressed MYC has been shown to stimulate the main processes of oncogenesis: uncontrolled growth, unlimited cell divisions, avoidance of apoptosis and immune response, changes in cellular metabolism, genomic instability, metastasis, and angiogenesis. Thus, controlling the expression of MYC is considered as an approach for targeted cancer treatment. Since c-Myc is also a crucial regulator of many cellular processes in healthy cells, it is necessary to find ways for selective regulation of MYC expression in tumor cells. Many recent studies have demonstrated that non-coding RNAs play an important role in the regulation of the transcription and translation of this gene and some RNAs directly interact with the c-Myc protein, affecting its stability. In this review, we summarize current data on the regulation of MYC by various non-coding RNAs that can potentially be targeted in specific tumor types. MDPI 2021-07-30 /pmc/articles/PMC8389562/ /pubmed/34440124 http://dx.doi.org/10.3390/biomedicines9080921 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stasevich, Ekaterina Mikhailovna
Murashko, Matvey Mikhailovich
Zinevich, Lyudmila Sergeevna
Demin, Denis Eriksonovich
Schwartz, Anton Markovich
The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer
title The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer
title_full The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer
title_fullStr The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer
title_full_unstemmed The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer
title_short The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer
title_sort role of non-coding rnas in the regulation of the proto-oncogene myc in different types of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389562/
https://www.ncbi.nlm.nih.gov/pubmed/34440124
http://dx.doi.org/10.3390/biomedicines9080921
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