Cargando…

Local Inhibition of Indoleamine 2,3-Dioxygenase Mitigates Renal Fibrosis

Chronic kidney disease (CKD) is a major global health concern and renal fibrosis is an integral part of the pathophysiological mechanism underlying disease progression. In CKD patients, the majority of metabolic pathways are in disarray and perturbations in enzyme activity most likely contribute to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jensen, Camilla Grønkjær, Jensen, Michael Schou, Tingskov, Stine Julie, Olinga, Peter, Nørregaard, Rikke, Mutsaers, Henricus A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389588/ https://www.ncbi.nlm.nih.gov/pubmed/34440060 http://dx.doi.org/10.3390/biomedicines9080856

Ejemplares similares

EP(1) receptor antagonism mitigates early and late stage renal fibrosis
por: Kresse, Jean‐Claude, et al.
Publicado: (2022)

Activation of the prostaglandin E(2) EP(2) receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices
por: Jensen, Michael Schou, et al.
Publicado: (2019)

An animal-free preclinical drug screening platform based on human precision-cut kidney slices
por: Mutsaers, Henricus A. M., et al.
Publicado: (2023)

Editorial: Organ Fibrosis: Pathogenesis, Biomarkers and Therapeutic Targets
por: Mutsaers, Henricus A. M., et al.
Publicado: (2021)

P2X(7) accelerate tissue fibrosis via metalloproteinase 8‐dependent macrophage infiltration in a murine model of unilateral ureteral obstruction
por: Therkildsen, Jacob Rudjord, et al.
Publicado: (2023)

Prostaglandin E2 receptors as therapeutic targets in renal fibrosis
por: Mutsaers, Henricus A.M., et al.
Publicado: (2022)

Transcutaneous measurement of renal function in two rodent models of obstructive nephropathy
por: Jensen, Michael Schou, et al.
Publicado: (2023)

Localization of Indoleamine 2,3-Dioxygenase-1 and Indoleamine 2,3-Dioxygenase-2 at the Human Maternal-Fetal Interface
por: Kudo, Yoshiki, et al.
Publicado: (2020)

Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis
por: Nørregaard, Rikke, et al.
Publicado: (2023)

Editorial: Targeting Indoleamine 2,3-dioxygenases and Tryptophan Dioxygenase for Cancer Immunotherapy
por: Brochez, Lieve, et al.
Publicado: (2021)

Targeting the indoleamine 2,3-dioxygenase pathway in cancer
por: Moon, Yong Wha, et al.
Publicado: (2015)

Natural CD4(+) T-Cell Responses against Indoleamine 2,3-Dioxygenase
por: Munir, Shamaila, et al.
Publicado: (2012)

Editorial: Organ Fibrosis: Triggers, Pathways, and Cellular Plasticity
por: Mutsaers, Henricus A. M., et al.
Publicado: (2016)

The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl(4)-Induced Liver Fibrosis in Mice
por: Ogiso, Hideyuki, et al.
Publicado: (2016)

The Mechanism of Substrate Inhibition in Human Indoleamine 2,3-Dioxygenase
por: Efimov, Igor, et al.
Publicado: (2012)

Indoleamine-2,3-dioxygenase activity induces neutrophil apoptosis
por: Van der Sluijs, K, et al.
Publicado: (2011)

Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia
por: Padberg, Jan-Sören, et al.
Publicado: (2012)

The role of placental indoleamine 2,3-dioxygenase in human pregnancy
por: Kudo, Yoshiki
Publicado: (2013)

Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry
por: Coletti, Alice, et al.
Publicado: (2017)

Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?
por: Mellor, Andrew L., et al.
Publicado: (2017)

Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract
por: Acovic, Aleksandar, et al.
Publicado: (2018)

Role of indoleamine 2,3-dioxygenase in testicular immune-privilege
por: Gualdoni, Gisela S., et al.
Publicado: (2019)

A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases
por: Zhou, Qihui, et al.
Publicado: (2021)

Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase
por: Bracho-Sanchez, Evelyn, et al.
Publicado: (2023)

Association of a functional Indoleamine 2,3-dioxygenase 2 genotype with specific immune responses
por: Køllgaard, Tania, et al.
Publicado: (2012)

Tamoxifen Affects Aquaporin-3 Expression and Subcellular Localization in Rat and Human Renal Collecting Ducts
por: Tingskov, Stine Julie, et al.
Publicado: (2023)

Expression of indoleamine 2.3-dioxygenase by tumors induces local and systemic immunosuppressive effects in a murine melanoma model
por: Holmgaard, Rikke B, et al.
Publicado: (2014)

Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells
por: Eleftheriadis, Theodoros, et al.
Publicado: (2021)

Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase
por: Yoshioka, Saeko, et al.
Publicado: (2022)

Indoleamine 2,3-Dioxygenase in Human Hematopoietic Stem Cell Transplantation
por: Jürgens, Birgit, et al.
Publicado: (2010)

The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancer
por: Gao, Yan-Fang, et al.
Publicado: (2009)

The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis
por: Shibata, Yuhei, et al.
Publicado: (2016)

Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors
por: Zulfiqar, Bilal, et al.
Publicado: (2017)

The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
por: Hornyák, Lilla, et al.
Publicado: (2018)

Hypoxia enhances indoleamine 2,3-dioxygenase production in dendritic cells
por: Song, Xiang, et al.
Publicado: (2018)

Expression and Prognostic Value of Indoleamine 2,3-dioxygenase in Pancreatic Cancer
por: Zhang, Tao, et al.
Publicado: (2017)

Comprehensive behavioral analysis of indoleamine 2,3‐dioxygenase knockout mice
por: Hirata, Nao, et al.
Publicado: (2018)

Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy
por: Deng, Ning, et al.
Publicado: (2021)

Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System
por: Bello, Corina, et al.
Publicado: (2021)

Indoleamine 2,3-Dioxygenase: A Novel Immunotherapeutic Target for Osteosarcoma
por: Farooq, Asim, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0ingjacin1snjne3d4b9qmsa32