Cargando…

High Na(+) Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells

Our knowledge on essential hypertension is vast, and its treatment is well known. Not all hypertensives are salt-sensitive. The available evidence suggests that even normotensive individuals are at high cardiovascular risk and lower survival rate, as blood pressure eventually rises later in life wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Bkaily, Ghassan, Simon, Yanick, Jazzar, Ashley, Najibeddine, Houssein, Normand, Alexandre, Jacques, Danielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389691/
https://www.ncbi.nlm.nih.gov/pubmed/34440087
http://dx.doi.org/10.3390/biomedicines9080883
_version_ 1783742917747146752
author Bkaily, Ghassan
Simon, Yanick
Jazzar, Ashley
Najibeddine, Houssein
Normand, Alexandre
Jacques, Danielle
author_facet Bkaily, Ghassan
Simon, Yanick
Jazzar, Ashley
Najibeddine, Houssein
Normand, Alexandre
Jacques, Danielle
author_sort Bkaily, Ghassan
collection PubMed
description Our knowledge on essential hypertension is vast, and its treatment is well known. Not all hypertensives are salt-sensitive. The available evidence suggests that even normotensive individuals are at high cardiovascular risk and lower survival rate, as blood pressure eventually rises later in life with a high salt diet. In addition, little is known about high sodium (Na(+)) salt diet-sensitive hypertension. There is no doubt that direct and indirect Na(+) transporters, such as the Na/Ca exchanger and the Na/H exchanger, and the Na/K pump could be implicated in the development of high salt-induced hypertension in humans. These mechanisms could be involved following the destruction of the cell membrane glycocalyx and changes in vascular endothelial and smooth muscle cells membranes’ permeability and osmolarity. Thus, it is vital to determine the membrane and intracellular mechanisms implicated in this type of hypertension and its treatment.
format Online
Article
Text
id pubmed-8389691
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83896912021-08-27 High Na(+) Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells Bkaily, Ghassan Simon, Yanick Jazzar, Ashley Najibeddine, Houssein Normand, Alexandre Jacques, Danielle Biomedicines Review Our knowledge on essential hypertension is vast, and its treatment is well known. Not all hypertensives are salt-sensitive. The available evidence suggests that even normotensive individuals are at high cardiovascular risk and lower survival rate, as blood pressure eventually rises later in life with a high salt diet. In addition, little is known about high sodium (Na(+)) salt diet-sensitive hypertension. There is no doubt that direct and indirect Na(+) transporters, such as the Na/Ca exchanger and the Na/H exchanger, and the Na/K pump could be implicated in the development of high salt-induced hypertension in humans. These mechanisms could be involved following the destruction of the cell membrane glycocalyx and changes in vascular endothelial and smooth muscle cells membranes’ permeability and osmolarity. Thus, it is vital to determine the membrane and intracellular mechanisms implicated in this type of hypertension and its treatment. MDPI 2021-07-24 /pmc/articles/PMC8389691/ /pubmed/34440087 http://dx.doi.org/10.3390/biomedicines9080883 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bkaily, Ghassan
Simon, Yanick
Jazzar, Ashley
Najibeddine, Houssein
Normand, Alexandre
Jacques, Danielle
High Na(+) Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells
title High Na(+) Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells
title_full High Na(+) Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells
title_fullStr High Na(+) Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells
title_full_unstemmed High Na(+) Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells
title_short High Na(+) Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells
title_sort high na(+) salt diet and remodeling of vascular smooth muscle and endothelial cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389691/
https://www.ncbi.nlm.nih.gov/pubmed/34440087
http://dx.doi.org/10.3390/biomedicines9080883
work_keys_str_mv AT bkailyghassan highnasaltdietandremodelingofvascularsmoothmuscleandendothelialcells
AT simonyanick highnasaltdietandremodelingofvascularsmoothmuscleandendothelialcells
AT jazzarashley highnasaltdietandremodelingofvascularsmoothmuscleandendothelialcells
AT najibeddinehoussein highnasaltdietandremodelingofvascularsmoothmuscleandendothelialcells
AT normandalexandre highnasaltdietandremodelingofvascularsmoothmuscleandendothelialcells
AT jacquesdanielle highnasaltdietandremodelingofvascularsmoothmuscleandendothelialcells