Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors†

[Image: see text] We have recently described a new generation of potent human immunodeficiency virus (HIV) and EV-A71 entry inhibitors. The prototypes contain three or four tryptophan (Trp) residues bearing an isophthalic acid moiety at the C2 position of each side-chain indole ring. This work is no...

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Detalles Bibliográficos
Autores principales: Martí-Marí, Olaia, Martínez-Gualda, Belén, de la Puente-Secades, Sofía, Mills, Alberto, Quesada, Ernesto, Abdelnabi, Rana, Sun, Liang, Boonen, Arnaud, Noppen, Sam, Neyts, Johan, Schols, Dominique, Camarasa, María-José, Gago, Federico, San-Félix, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389807/
https://www.ncbi.nlm.nih.gov/pubmed/34229438
http://dx.doi.org/10.1021/acs.jmedchem.1c00315

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