Cargando…

α/β-Hydrolase Domain (ABHD) Inhibitors as New Potential Therapeutic Options against Lipid-Related Diseases

[Image: see text] Much of the experimental evidence in the literature has linked altered lipid metabolism to severe diseases such as cancer, obesity, cardiovascular pathologies, diabetes, and neurodegenerative diseases. Therefore, targeting key effectors of the dysregulated lipid metabolism may repr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bononi, Giulia, Tuccinardi, Tiziano, Rizzolio, Flavio, Granchi, Carlotta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389839/ https://www.ncbi.nlm.nih.gov/pubmed/34213320 http://dx.doi.org/10.1021/acs.jmedchem.1c00624

Ejemplares similares

α/β-Hydrolase Domain-Containing 6 (ABHD6)— A Multifunctional Lipid Hydrolase
por: Pusch, Lisa-Maria, et al.
Publicado: (2022)

Application of MM-PBSA Methods in Virtual Screening
por: Poli, Giulio, et al.
Publicado: (2020)

Discovery of Triterpenoids as Reversible Inhibitors of α/β-hydrolase Domain Containing 12 (ABHD12)
por: Parkkari, Teija, et al.
Publicado: (2014)

Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors
por: Di Stefano, Miriana, et al.
Publicado: (2022)

α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate
por: Pribasnig, Maria A., et al.
Publicado: (2015)

α/β-Hydrolase Domain Containing Protein 15 (ABHD15) – an Adipogenic Protein Protecting from Apoptosis
por: Walenta, Evelyn, et al.
Publicado: (2013)

Comparative molecular field analysis and molecular dynamics studies of α/β hydrolase domain containing 6 (ABHD6) inhibitors
por: Kaczor, Agnieszka A., et al.
Publicado: (2015)

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors
por: Granchi, Carlotta, et al.
Publicado: (2017)

Distinct roles for α-β hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling
por: Lord, Caleb C., et al.
Publicado: (2012)

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
por: Poli, Giulio, et al.
Publicado: (2019)

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors
por: Poli, Giulio, et al.
Publicado: (2018)

Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12
por: Ahonen, Tiina J., et al.
Publicado: (2023)

Editorial: Peptidyl-Prolyl Isomerases in Human Pathologies
por: Tuccinardi, Tiziano, et al.
Publicado: (2019)

A Guide to PIN1 Function and Mutations Across Cancers
por: El Boustani, Maguie, et al.
Publicado: (2019)

STARD3: A Prospective Target for Cancer Therapy
por: Asif, Kanwal, et al.
Publicado: (2021)

Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives
por: Bononi, Giulia, et al.
Publicado: (2022)

Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model
por: Paterni, Ilaria, et al.
Publicado: (2015)

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors
por: Savinainen, J R, et al.
Publicado: (2012)

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
por: Bononi, Giulia, et al.
Publicado: (2022)

Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin
por: Price, Tara R., et al.
Publicado: (2023)

Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin
por: Price, Tara R., et al.
Publicado: (2023)

The Inhibitory Effect of α/β-Hydrolase Domain-Containing 6 (ABHD6) on the Surface Targeting of GluA2- and GluA3-Containing AMPA Receptors
por: Wei, Mengping, et al.
Publicado: (2017)

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors
por: Poli, Giulio, et al.
Publicado: (2017)

Molecular characterization of human ABHD2 as TAG lipase and ester hydrolase
por: M., Naresh Kumar, et al.
Publicado: (2016)

New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy
por: Poli, Giulio, et al.
Publicado: (2021)

New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds
por: Bononi, Giulia, et al.
Publicado: (2022)

Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids
por: Joshi, Alaumy, et al.
Publicado: (2018)

The History of Nanoscience and Nanotechnology: From Chemical–Physical Applications to Nanomedicine
por: Bayda, Samer, et al.
Publicado: (2019)

Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors
por: Granchi, Carlotta, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents †
por: D’Andrea, Felicia, et al.
Publicado: (2019)

Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status
por: Miralpeix, Cristina, et al.
Publicado: (2021)

The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome
por: Westenbroek, Ruth, et al.
Publicado: (2023)

Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay
por: Kamat, Siddhesh S., et al.
Publicado: (2015)

Biochemical and Proteomic Characterization of Recombinant Human α/β Hydrolase Domain 6
por: Shields, Christina Miyabe, et al.
Publicado: (2019)

Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study
por: Jha, Vibhu, et al.
Publicado: (2020)

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation
por: Stöckli, Jacqueline, et al.
Publicado: (2019)

ABHD5—A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions
por: Schratter, Margarita, et al.
Publicado: (2022)

Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease
por: Xu, Jun, et al.
Publicado: (2018)

The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly
por: Vieyres, Gabrielle, et al.
Publicado: (2020)

ABHD11 Is Critical for Embryonic Stem Cell Expansion, Differentiation and Lipid Metabolic Homeostasis
por: Liu, Gaoke, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_idqid7claatsfvfmut0lk03ik8