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The Relationship Between Vitamin D and Asthma Exacerbation

Asthma is a chronic airway inflammatory condition that affects millions of people worldwide. It presents with reversible bronchoconstriction that makes it difficult for patients to breathe. Asthma flare-ups have several triggers, but the symptoms are similar, including wheezing, coughing, shortness...

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Autores principales: Ogeyingbo, Opemipo D, Ahmed, Rowan, Gyawali, Mallika, Venkatesan, Nanditha, Bhandari, Renu, Botleroo, Rinky A, Kareem, Roaa, Elshaikh, Abeer O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389855/
https://www.ncbi.nlm.nih.gov/pubmed/34462708
http://dx.doi.org/10.7759/cureus.17279
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author Ogeyingbo, Opemipo D
Ahmed, Rowan
Gyawali, Mallika
Venkatesan, Nanditha
Bhandari, Renu
Botleroo, Rinky A
Kareem, Roaa
Elshaikh, Abeer O
author_facet Ogeyingbo, Opemipo D
Ahmed, Rowan
Gyawali, Mallika
Venkatesan, Nanditha
Bhandari, Renu
Botleroo, Rinky A
Kareem, Roaa
Elshaikh, Abeer O
author_sort Ogeyingbo, Opemipo D
collection PubMed
description Asthma is a chronic airway inflammatory condition that affects millions of people worldwide. It presents with reversible bronchoconstriction that makes it difficult for patients to breathe. Asthma flare-ups have several triggers, but the symptoms are similar, including wheezing, coughing, shortness of breath, and chest tightness. Severe asthma exacerbation is described as symptomatic asthma that is unresponsive to inhaled asthma medications and is only responsive to steroids in oral or intravenous forms. Asthma-related deaths occur during episodes of asthma exacerbation. Vitamin D is a steroid-derived vitamin produced by the body and found in some foods. Administration of doses of vitamin D can also help maintain an adequate level of the vitamin. Vitamin D plays a vital role in regulating the level of calcium in the body and bone remodeling processes. It also has an immunomodulatory effect on innate and adaptive immunity within the body and that partially explains its links to inflammation-induced epithelial changes seen in asthma. We conducted this literature review by selecting articles from PubMed and Cumulated Index to Nursing and Allied Health Literature (CINAHL) Plus databases to investigate the relationship between vitamin D level and asthma exacerbation. From the studies, we found that asthmatic patients have low vitamin D levels during an asthma exacerbation. However, supplementing vitamin D may not reduce the rates of asthma exacerbation except in adult asthmatic patients with low levels of vitamin D.
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spelling pubmed-83898552021-08-29 The Relationship Between Vitamin D and Asthma Exacerbation Ogeyingbo, Opemipo D Ahmed, Rowan Gyawali, Mallika Venkatesan, Nanditha Bhandari, Renu Botleroo, Rinky A Kareem, Roaa Elshaikh, Abeer O Cureus Internal Medicine Asthma is a chronic airway inflammatory condition that affects millions of people worldwide. It presents with reversible bronchoconstriction that makes it difficult for patients to breathe. Asthma flare-ups have several triggers, but the symptoms are similar, including wheezing, coughing, shortness of breath, and chest tightness. Severe asthma exacerbation is described as symptomatic asthma that is unresponsive to inhaled asthma medications and is only responsive to steroids in oral or intravenous forms. Asthma-related deaths occur during episodes of asthma exacerbation. Vitamin D is a steroid-derived vitamin produced by the body and found in some foods. Administration of doses of vitamin D can also help maintain an adequate level of the vitamin. Vitamin D plays a vital role in regulating the level of calcium in the body and bone remodeling processes. It also has an immunomodulatory effect on innate and adaptive immunity within the body and that partially explains its links to inflammation-induced epithelial changes seen in asthma. We conducted this literature review by selecting articles from PubMed and Cumulated Index to Nursing and Allied Health Literature (CINAHL) Plus databases to investigate the relationship between vitamin D level and asthma exacerbation. From the studies, we found that asthmatic patients have low vitamin D levels during an asthma exacerbation. However, supplementing vitamin D may not reduce the rates of asthma exacerbation except in adult asthmatic patients with low levels of vitamin D. Cureus 2021-08-18 /pmc/articles/PMC8389855/ /pubmed/34462708 http://dx.doi.org/10.7759/cureus.17279 Text en Copyright © 2021, Ogeyingbo et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ogeyingbo, Opemipo D
Ahmed, Rowan
Gyawali, Mallika
Venkatesan, Nanditha
Bhandari, Renu
Botleroo, Rinky A
Kareem, Roaa
Elshaikh, Abeer O
The Relationship Between Vitamin D and Asthma Exacerbation
title The Relationship Between Vitamin D and Asthma Exacerbation
title_full The Relationship Between Vitamin D and Asthma Exacerbation
title_fullStr The Relationship Between Vitamin D and Asthma Exacerbation
title_full_unstemmed The Relationship Between Vitamin D and Asthma Exacerbation
title_short The Relationship Between Vitamin D and Asthma Exacerbation
title_sort relationship between vitamin d and asthma exacerbation
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389855/
https://www.ncbi.nlm.nih.gov/pubmed/34462708
http://dx.doi.org/10.7759/cureus.17279
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