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Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)

[Image: see text] Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) plays an important role in one-carbon metabolism. The MTHFD2 gene is upregulated in various cancers but very low or undetectable in normal proliferating cells, and therefore a potential target for cancer treatment. In this study, w...

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Detalles Bibliográficos
Autores principales:	Lee, Lung-Chun, Peng, Yi-Hui, Chang, Hsin-Huei, Hsu, Tsu, Lu, Cheng-Tai, Huang, Chih-Hsiang, Hsueh, Ching-Cheng, Kung, Fang-Chun, Kuo, Ching-Chuan, Jiaang, Weir-Torn, Wu, Su-Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389891/ https://www.ncbi.nlm.nih.gov/pubmed/34337952 http://dx.doi.org/10.1021/acs.jmedchem.1c00663

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