First-in-Class Cyclic Temporin L Analogue: Design, Synthesis, and Antimicrobial Assessment

[Image: see text] The pharmacodynamic and pharmacokinetic properties of bioactive peptides can be modulated by introducing conformational constraints such as intramolecular macrocyclizations, which can involve either the backbone and/or side chains. Herein, we aimed at increasing the α-helicity cont...

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Detalles Bibliográficos
Autores principales: Bellavita, Rosa, Casciaro, Bruno, Di Maro, Salvatore, Brancaccio, Diego, Carotenuto, Alfonso, Falanga, Annarita, Cappiello, Floriana, Buommino, Elisabetta, Galdiero, Stefania, Novellino, Ettore, Grossmann, Tom N., Mangoni, Maria Luisa, Merlino, Francesco, Grieco, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389922/
https://www.ncbi.nlm.nih.gov/pubmed/34296619
http://dx.doi.org/10.1021/acs.jmedchem.1c01033

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