Small airway function in Finnish COVID-19 survivors

Follow-up studies of COVID-19 patients have found lung function impairment up to six months after initial infection, but small airway function has not previously been studied. Patients (n = 20) hospitalised for a severe SARS-CoV-2 infection underwent spirometry, impulse oscillometry, and multiple me...

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Autores principales: Lindahl, Anna, Reijula, Jere, Malmberg, Leo Pekka, Aro, Miia, Vasankari, Tuula, Mäkelä, Mika Juhani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390085/
https://www.ncbi.nlm.nih.gov/pubmed/34446020
http://dx.doi.org/10.1186/s12931-021-01830-9
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author Lindahl, Anna
Reijula, Jere
Malmberg, Leo Pekka
Aro, Miia
Vasankari, Tuula
Mäkelä, Mika Juhani
author_facet Lindahl, Anna
Reijula, Jere
Malmberg, Leo Pekka
Aro, Miia
Vasankari, Tuula
Mäkelä, Mika Juhani
author_sort Lindahl, Anna
collection PubMed
description Follow-up studies of COVID-19 patients have found lung function impairment up to six months after initial infection, but small airway function has not previously been studied. Patients (n = 20) hospitalised for a severe SARS-CoV-2 infection underwent spirometry, impulse oscillometry, and multiple measurements of alveolar nitric oxide three to six months after acute infection. None of the patients had small airway obstruction, nor increased nitric oxide concentration in the alveolar level. None of the patients had a reduced FEV(1)/FVC or significant bronchodilator responses in IOS or spirometry. In conclusion, we found no evidence of inflammation or dysfunction in the small airways.
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spelling pubmed-83900852021-08-27 Small airway function in Finnish COVID-19 survivors Lindahl, Anna Reijula, Jere Malmberg, Leo Pekka Aro, Miia Vasankari, Tuula Mäkelä, Mika Juhani Respir Res Letter to the Editor Follow-up studies of COVID-19 patients have found lung function impairment up to six months after initial infection, but small airway function has not previously been studied. Patients (n = 20) hospitalised for a severe SARS-CoV-2 infection underwent spirometry, impulse oscillometry, and multiple measurements of alveolar nitric oxide three to six months after acute infection. None of the patients had small airway obstruction, nor increased nitric oxide concentration in the alveolar level. None of the patients had a reduced FEV(1)/FVC or significant bronchodilator responses in IOS or spirometry. In conclusion, we found no evidence of inflammation or dysfunction in the small airways. BioMed Central 2021-08-26 2021 /pmc/articles/PMC8390085/ /pubmed/34446020 http://dx.doi.org/10.1186/s12931-021-01830-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Lindahl, Anna
Reijula, Jere
Malmberg, Leo Pekka
Aro, Miia
Vasankari, Tuula
Mäkelä, Mika Juhani
Small airway function in Finnish COVID-19 survivors
title Small airway function in Finnish COVID-19 survivors
title_full Small airway function in Finnish COVID-19 survivors
title_fullStr Small airway function in Finnish COVID-19 survivors
title_full_unstemmed Small airway function in Finnish COVID-19 survivors
title_short Small airway function in Finnish COVID-19 survivors
title_sort small airway function in finnish covid-19 survivors
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390085/
https://www.ncbi.nlm.nih.gov/pubmed/34446020
http://dx.doi.org/10.1186/s12931-021-01830-9
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