Cargando…
Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study
INTRODUCTION: Patients with type 2 diabetes are widely prescribed metformin for controlling blood glucose levels to avoid related comorbidities. In Taiwan, traditional Chinese medicine (TCM) is also commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurren...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390129/ https://www.ncbi.nlm.nih.gov/pubmed/34457016 http://dx.doi.org/10.1155/2021/1298487 |
_version_ | 1783743027427147776 |
---|---|
author | Chen, Hsin-Hung Wu, Chien-Tung Tsai, Yueh-Ting Ho, Chun-Wei Hsieh, Ming-Chia Lai, Jung-Nien |
author_facet | Chen, Hsin-Hung Wu, Chien-Tung Tsai, Yueh-Ting Ho, Chun-Wei Hsieh, Ming-Chia Lai, Jung-Nien |
author_sort | Chen, Hsin-Hung |
collection | PubMed |
description | INTRODUCTION: Patients with type 2 diabetes are widely prescribed metformin for controlling blood glucose levels to avoid related comorbidities. In Taiwan, traditional Chinese medicine (TCM) is also commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence of kidney failure. However, the effect of combinational therapy of TCM and oral antidiabetic drugs is still unclear. This study aims to estimate their efficacy in delaying insulin use. MATERIALS AND METHODS: This case-control study was conducted using one million randomized samples from the National Health Insurance Research Database in Taiwan. The effects of TCM and LWDHW were estimated using the Cox proportional hazards model. RESULTS: In this study, 70,036 diabetic patients were enrolled; of them, 17,451 (24.9%) used insulin, while the rest (52,585, 75.1%) did not. TCM users had a lower risk for insulin use (HR: 0.58, 95% CI: 0.56–0.60). LWDHW users had a lower risk compared with patients who used other TCM (HR: 0.86, 95% CI: 0.82–0.90) and presented a dose-dependent effect. CONCLUSION: The use of LWDHW and oral antidiabetic drugs is highly associated with the delay in the use of insulin. Clinical practitioners may take them into consideration when treating patients with type 2 diabetes. |
format | Online Article Text |
id | pubmed-8390129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-83901292021-08-27 Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study Chen, Hsin-Hung Wu, Chien-Tung Tsai, Yueh-Ting Ho, Chun-Wei Hsieh, Ming-Chia Lai, Jung-Nien Evid Based Complement Alternat Med Research Article INTRODUCTION: Patients with type 2 diabetes are widely prescribed metformin for controlling blood glucose levels to avoid related comorbidities. In Taiwan, traditional Chinese medicine (TCM) is also commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence of kidney failure. However, the effect of combinational therapy of TCM and oral antidiabetic drugs is still unclear. This study aims to estimate their efficacy in delaying insulin use. MATERIALS AND METHODS: This case-control study was conducted using one million randomized samples from the National Health Insurance Research Database in Taiwan. The effects of TCM and LWDHW were estimated using the Cox proportional hazards model. RESULTS: In this study, 70,036 diabetic patients were enrolled; of them, 17,451 (24.9%) used insulin, while the rest (52,585, 75.1%) did not. TCM users had a lower risk for insulin use (HR: 0.58, 95% CI: 0.56–0.60). LWDHW users had a lower risk compared with patients who used other TCM (HR: 0.86, 95% CI: 0.82–0.90) and presented a dose-dependent effect. CONCLUSION: The use of LWDHW and oral antidiabetic drugs is highly associated with the delay in the use of insulin. Clinical practitioners may take them into consideration when treating patients with type 2 diabetes. Hindawi 2021-08-19 /pmc/articles/PMC8390129/ /pubmed/34457016 http://dx.doi.org/10.1155/2021/1298487 Text en Copyright © 2021 Hsin-Hung Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chen, Hsin-Hung Wu, Chien-Tung Tsai, Yueh-Ting Ho, Chun-Wei Hsieh, Ming-Chia Lai, Jung-Nien Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study |
title | Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study |
title_full | Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study |
title_fullStr | Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study |
title_full_unstemmed | Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study |
title_short | Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study |
title_sort | liu wei di huang wan and the delay of insulin use in patients with type 2 diabetes in taiwan: a nationwide study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390129/ https://www.ncbi.nlm.nih.gov/pubmed/34457016 http://dx.doi.org/10.1155/2021/1298487 |
work_keys_str_mv | AT chenhsinhung liuweidihuangwanandthedelayofinsulinuseinpatientswithtype2diabetesintaiwananationwidestudy AT wuchientung liuweidihuangwanandthedelayofinsulinuseinpatientswithtype2diabetesintaiwananationwidestudy AT tsaiyuehting liuweidihuangwanandthedelayofinsulinuseinpatientswithtype2diabetesintaiwananationwidestudy AT hochunwei liuweidihuangwanandthedelayofinsulinuseinpatientswithtype2diabetesintaiwananationwidestudy AT hsiehmingchia liuweidihuangwanandthedelayofinsulinuseinpatientswithtype2diabetesintaiwananationwidestudy AT laijungnien liuweidihuangwanandthedelayofinsulinuseinpatientswithtype2diabetesintaiwananationwidestudy |