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Patterns of negative seroconversion in ongoing surveys of SARS-CoV-2 antibodies among workers in New York’s largest healthcare system

OBJECTIVES: Given the importance of continued COVID-19 surveillance, our objective was to present findings from a short follow-up survey of workforce SARS-CoV-2 antibody testing in previously seropositive participants and describe associations between work locations and negative seroconversion. METH...

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Autores principales: Sembajwe, Grace, Rasul, Rehana, Jacobs, Yehuda, Edwards, Keisha, Chambers Lewis, Lorraine, Chang, Tylis, Lowe, William, Moline, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390144/
https://www.ncbi.nlm.nih.gov/pubmed/34433658
http://dx.doi.org/10.1136/oemed-2021-107382
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author Sembajwe, Grace
Rasul, Rehana
Jacobs, Yehuda
Edwards, Keisha
Chambers Lewis, Lorraine
Chang, Tylis
Lowe, William
Moline, Jacqueline
author_facet Sembajwe, Grace
Rasul, Rehana
Jacobs, Yehuda
Edwards, Keisha
Chambers Lewis, Lorraine
Chang, Tylis
Lowe, William
Moline, Jacqueline
author_sort Sembajwe, Grace
collection PubMed
description OBJECTIVES: Given the importance of continued COVID-19 surveillance, our objective was to present findings from a short follow-up survey of workforce SARS-CoV-2 antibody testing in previously seropositive participants and describe associations between work locations and negative seroconversion. METHODS: We conducted a follow-up cross-sectional survey on previously seropositive healthcare workers, using questionnaires and serology testing. Eligible employees previously consented to be contacted were invited by email to participate in a survey and laboratory blood draws. SAS V.9.4 was used to describe employee characteristics and seroconversion status. Binomial regression models were used to calculate unadjusted and adjusted prevalence ratios (PRs) of seronegativity. The multivariable analyses included age, gender, race/ethnicity, region of residence, work location, prior diagnosis/PCR results and days between antibody tests. Unadjusted and adjusted PRs 95% CIs and p values were reported. RESULTS: Of the 3990 employees emailed in the follow-up, 1631 completed an exposure survey and generated a blood-draw requisition form. Average time between serology testing was 4 months. Of the 955 employees with complete serology results, 79.1% were female, 53.4% were white and 46.4% resided in Long Island; 176 participants seroconverted to negative. In multivariable regression analyses adjusted for gender, race/ethnicity and region of residence, younger employees (<20–30 years), intensive care unit workers and those with no/negative prior PCR results were more likely to have negative seroconversion. CONCLUSIONS AND RELEVANCE: Patterns of negative seroconversion showed significant differences by sociodemographic and workplace characteristics. These results contribute information to workplace serosurveillance.
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spelling pubmed-83901442021-08-27 Patterns of negative seroconversion in ongoing surveys of SARS-CoV-2 antibodies among workers in New York’s largest healthcare system Sembajwe, Grace Rasul, Rehana Jacobs, Yehuda Edwards, Keisha Chambers Lewis, Lorraine Chang, Tylis Lowe, William Moline, Jacqueline Occup Environ Med Workplace OBJECTIVES: Given the importance of continued COVID-19 surveillance, our objective was to present findings from a short follow-up survey of workforce SARS-CoV-2 antibody testing in previously seropositive participants and describe associations between work locations and negative seroconversion. METHODS: We conducted a follow-up cross-sectional survey on previously seropositive healthcare workers, using questionnaires and serology testing. Eligible employees previously consented to be contacted were invited by email to participate in a survey and laboratory blood draws. SAS V.9.4 was used to describe employee characteristics and seroconversion status. Binomial regression models were used to calculate unadjusted and adjusted prevalence ratios (PRs) of seronegativity. The multivariable analyses included age, gender, race/ethnicity, region of residence, work location, prior diagnosis/PCR results and days between antibody tests. Unadjusted and adjusted PRs 95% CIs and p values were reported. RESULTS: Of the 3990 employees emailed in the follow-up, 1631 completed an exposure survey and generated a blood-draw requisition form. Average time between serology testing was 4 months. Of the 955 employees with complete serology results, 79.1% were female, 53.4% were white and 46.4% resided in Long Island; 176 participants seroconverted to negative. In multivariable regression analyses adjusted for gender, race/ethnicity and region of residence, younger employees (<20–30 years), intensive care unit workers and those with no/negative prior PCR results were more likely to have negative seroconversion. CONCLUSIONS AND RELEVANCE: Patterns of negative seroconversion showed significant differences by sociodemographic and workplace characteristics. These results contribute information to workplace serosurveillance. BMJ Publishing Group 2021-11 2021-08-25 /pmc/articles/PMC8390144/ /pubmed/34433658 http://dx.doi.org/10.1136/oemed-2021-107382 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Workplace
Sembajwe, Grace
Rasul, Rehana
Jacobs, Yehuda
Edwards, Keisha
Chambers Lewis, Lorraine
Chang, Tylis
Lowe, William
Moline, Jacqueline
Patterns of negative seroconversion in ongoing surveys of SARS-CoV-2 antibodies among workers in New York’s largest healthcare system
title Patterns of negative seroconversion in ongoing surveys of SARS-CoV-2 antibodies among workers in New York’s largest healthcare system
title_full Patterns of negative seroconversion in ongoing surveys of SARS-CoV-2 antibodies among workers in New York’s largest healthcare system
title_fullStr Patterns of negative seroconversion in ongoing surveys of SARS-CoV-2 antibodies among workers in New York’s largest healthcare system
title_full_unstemmed Patterns of negative seroconversion in ongoing surveys of SARS-CoV-2 antibodies among workers in New York’s largest healthcare system
title_short Patterns of negative seroconversion in ongoing surveys of SARS-CoV-2 antibodies among workers in New York’s largest healthcare system
title_sort patterns of negative seroconversion in ongoing surveys of sars-cov-2 antibodies among workers in new york’s largest healthcare system
topic Workplace
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390144/
https://www.ncbi.nlm.nih.gov/pubmed/34433658
http://dx.doi.org/10.1136/oemed-2021-107382
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