Irisin Attenuates Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in the H9C2 Cellular Model of Septic Cardiomyopathy through Augmenting Fundc1-Dependent Mitophagy

In the present study, we used lipopolysaccharide- (LPS-) stimulated H9C2 cardiomyocytes to investigate whether irisin treatment attenuates septic cardiomyopathy via Fundc1-related mitophagy. Fundc1 levels and mitophagy were significantly reduced in LPS-stimulated H9C2 cardiomyocytes but were signifi...

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Detalles Bibliográficos
Autores principales: Jiang, Xiaoqing, Cai, Shumin, Jin, Yinghui, Wu, Feng, He, Jing, Wu, Xixuan, Tan, Ying, Wang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390168/
https://www.ncbi.nlm.nih.gov/pubmed/34457111
http://dx.doi.org/10.1155/2021/2989974

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