Neurofilament light and heterogeneity of disease progression in amyotrophic lateral sclerosis: development and validation of a prediction model to improve interventional trials

BACKGROUND: Interventional trials in amyotrophic lateral sclerosis (ALS) suffer from the heterogeneity of the disease as it considerably reduces statistical power. We asked if blood neurofilament light chains (NfL) could be used to anticipate disease progression and increase trial power. METHODS: In...

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Detalles Bibliográficos
Autores principales: Witzel, Simon, Frauhammer, Felix, Steinacker, Petra, Devos, David, Pradat, Pierre-François, Meininger, Vincent, Halbgebauer, Steffen, Oeckl, Patrick, Schuster, Joachim, Anders, Simon, Dorst, Johannes, Otto, Markus, Ludolph, Albert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390195/
https://www.ncbi.nlm.nih.gov/pubmed/34433481
http://dx.doi.org/10.1186/s40035-021-00257-y

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