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Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort

BACKGROUND: Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, as gatekeepers against invading infectious agents through rapid secretion of im...

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Autores principales: Nabatanzi, Rose, Bayigga, Lois, Cose, Stephen, Canderan, Glenda, Rowland Jones, Sarah, Joloba, Moses, Nakanjako, Damalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390268/
https://www.ncbi.nlm.nih.gov/pubmed/34445953
http://dx.doi.org/10.1186/s12865-021-00450-8
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author Nabatanzi, Rose
Bayigga, Lois
Cose, Stephen
Canderan, Glenda
Rowland Jones, Sarah
Joloba, Moses
Nakanjako, Damalie
author_facet Nabatanzi, Rose
Bayigga, Lois
Cose, Stephen
Canderan, Glenda
Rowland Jones, Sarah
Joloba, Moses
Nakanjako, Damalie
author_sort Nabatanzi, Rose
collection PubMed
description BACKGROUND: Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, as gatekeepers against invading infectious agents through rapid secretion of immune regulatory cytokines. HIV associated destruction of mucosal lymphoid tissue depletes ILCs, among other immune dysfunctions. Studies have described limited restoration of ILCs during the first three years of combined antiretroviral therapy (cART). Little is known about restoration of ILCs during long-term cART, particularly in sub-Saharan Africa which hosts increasing numbers of adults with at least a decade of cART. RESULTS: We examined phenotypes and function of ILCs from peripheral blood mononuclear cells after 12 years of suppressive cART. We report that ILC1 frequencies (T-BET + CD127 + and CD161 +) were higher in cART-treated HIV-infected relative to age-matched health HIV-negative adults; P = 0.04 whereas ILC precursors (ILCP) were comparable in the two groups (P = 0.56). Interferon gamma (IFN-γ) secretion by ILC1 was higher among cART-treated HIV-infected relative to HIV-negative adults (P = 0.03). CONCLUSION: HIV associated alteration of ILC persisted during cART and may likely affect the quality of host innate and adaptive immune responses during long-term cART. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12865-021-00450-8.
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spelling pubmed-83902682021-08-27 Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort Nabatanzi, Rose Bayigga, Lois Cose, Stephen Canderan, Glenda Rowland Jones, Sarah Joloba, Moses Nakanjako, Damalie BMC Immunol Research BACKGROUND: Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, as gatekeepers against invading infectious agents through rapid secretion of immune regulatory cytokines. HIV associated destruction of mucosal lymphoid tissue depletes ILCs, among other immune dysfunctions. Studies have described limited restoration of ILCs during the first three years of combined antiretroviral therapy (cART). Little is known about restoration of ILCs during long-term cART, particularly in sub-Saharan Africa which hosts increasing numbers of adults with at least a decade of cART. RESULTS: We examined phenotypes and function of ILCs from peripheral blood mononuclear cells after 12 years of suppressive cART. We report that ILC1 frequencies (T-BET + CD127 + and CD161 +) were higher in cART-treated HIV-infected relative to age-matched health HIV-negative adults; P = 0.04 whereas ILC precursors (ILCP) were comparable in the two groups (P = 0.56). Interferon gamma (IFN-γ) secretion by ILC1 was higher among cART-treated HIV-infected relative to HIV-negative adults (P = 0.03). CONCLUSION: HIV associated alteration of ILC persisted during cART and may likely affect the quality of host innate and adaptive immune responses during long-term cART. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12865-021-00450-8. BioMed Central 2021-08-26 /pmc/articles/PMC8390268/ /pubmed/34445953 http://dx.doi.org/10.1186/s12865-021-00450-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Nabatanzi, Rose
Bayigga, Lois
Cose, Stephen
Canderan, Glenda
Rowland Jones, Sarah
Joloba, Moses
Nakanjako, Damalie
Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
title Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
title_full Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
title_fullStr Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
title_full_unstemmed Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
title_short Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
title_sort innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an african cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390268/
https://www.ncbi.nlm.nih.gov/pubmed/34445953
http://dx.doi.org/10.1186/s12865-021-00450-8
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