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Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell transplantation
Elderly patients with dementia suffer from cognitive dysfunctions and neuropsychiatric symptoms (NPS) such as anxiety and depression. Alzheimer’s disease (AD) is a form of age-related dementia, and loss of cholinergic neurons is intimately associated with development of AD symptoms. We and others ha...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Association for Laboratory Animal Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390309/ https://www.ncbi.nlm.nih.gov/pubmed/33828024 http://dx.doi.org/10.1538/expanim.21-0008 |
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author | Murayama, Masanori A. Arimitsu, Nagisa Shimizu, Jun Fujiwara, Naruyoshi Takai, Kenji Okada, Yoko Hirotsu, Chieko Takada, Erika Suzuki, Tomoko Suzuki, Noboru |
author_facet | Murayama, Masanori A. Arimitsu, Nagisa Shimizu, Jun Fujiwara, Naruyoshi Takai, Kenji Okada, Yoko Hirotsu, Chieko Takada, Erika Suzuki, Tomoko Suzuki, Noboru |
author_sort | Murayama, Masanori A. |
collection | PubMed |
description | Elderly patients with dementia suffer from cognitive dysfunctions and neuropsychiatric symptoms (NPS) such as anxiety and depression. Alzheimer’s disease (AD) is a form of age-related dementia, and loss of cholinergic neurons is intimately associated with development of AD symptoms. We and others have reported that neural cell transplantation ameliorated cognitive dysfunction in AD model mice. It remains largely unclear whether neural cell transplantation ameliorates the NPS of AD. It would be interesting to determine whether NPS correlates with cognitive dysfunctions before and after neural cell transplantation in AD model mice. Based on the revalidation of our previous data from a Morris water maze test, we found that neural cell transplantation improved anxiety and depression significantly and marginally affected locomotion activity in AD mice. A correlation analysis revealed that the spatial learning function of AD mice was correlated with their NPS scores both before and after cell transplantation in a similar manner. In contrast, in the mice subjected to cell transplantation, spatial reference memory function was not correlated with NPS scores. These results suggested the neural cell transplantation in the AD model mice significantly improved NPS to the same degree as cognitive dysfunctions, possibly via distinct mechanisms, such as the cholinergic and GABAergic systems. |
format | Online Article Text |
id | pubmed-8390309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83903092021-08-31 Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell transplantation Murayama, Masanori A. Arimitsu, Nagisa Shimizu, Jun Fujiwara, Naruyoshi Takai, Kenji Okada, Yoko Hirotsu, Chieko Takada, Erika Suzuki, Tomoko Suzuki, Noboru Exp Anim Original Elderly patients with dementia suffer from cognitive dysfunctions and neuropsychiatric symptoms (NPS) such as anxiety and depression. Alzheimer’s disease (AD) is a form of age-related dementia, and loss of cholinergic neurons is intimately associated with development of AD symptoms. We and others have reported that neural cell transplantation ameliorated cognitive dysfunction in AD model mice. It remains largely unclear whether neural cell transplantation ameliorates the NPS of AD. It would be interesting to determine whether NPS correlates with cognitive dysfunctions before and after neural cell transplantation in AD model mice. Based on the revalidation of our previous data from a Morris water maze test, we found that neural cell transplantation improved anxiety and depression significantly and marginally affected locomotion activity in AD mice. A correlation analysis revealed that the spatial learning function of AD mice was correlated with their NPS scores both before and after cell transplantation in a similar manner. In contrast, in the mice subjected to cell transplantation, spatial reference memory function was not correlated with NPS scores. These results suggested the neural cell transplantation in the AD model mice significantly improved NPS to the same degree as cognitive dysfunctions, possibly via distinct mechanisms, such as the cholinergic and GABAergic systems. Japanese Association for Laboratory Animal Science 2021-04-08 2021 /pmc/articles/PMC8390309/ /pubmed/33828024 http://dx.doi.org/10.1538/expanim.21-0008 Text en ©2021 Japanese Association for Laboratory Animal Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Murayama, Masanori A. Arimitsu, Nagisa Shimizu, Jun Fujiwara, Naruyoshi Takai, Kenji Okada, Yoko Hirotsu, Chieko Takada, Erika Suzuki, Tomoko Suzuki, Noboru Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell transplantation |
title | Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell
transplantation |
title_full | Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell
transplantation |
title_fullStr | Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell
transplantation |
title_full_unstemmed | Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell
transplantation |
title_short | Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell
transplantation |
title_sort | dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell
transplantation |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390309/ https://www.ncbi.nlm.nih.gov/pubmed/33828024 http://dx.doi.org/10.1538/expanim.21-0008 |
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