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Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases

The large MAF transcription factor group is a group of transcription factors with an acidic region, a basic region, and a leucine zipper region. Four types of MAF, MAFA, MAFB, c-MAF, and NRL, have been identified in humans and mice. In order to elucidate the functions of the large MAF transcription...

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Autor principal: Takahashi, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390310/
https://www.ncbi.nlm.nih.gov/pubmed/33762508
http://dx.doi.org/10.1538/expanim.21-0027
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author Takahashi, Satoru
author_facet Takahashi, Satoru
author_sort Takahashi, Satoru
collection PubMed
description The large MAF transcription factor group is a group of transcription factors with an acidic region, a basic region, and a leucine zipper region. Four types of MAF, MAFA, MAFB, c-MAF, and NRL, have been identified in humans and mice. In order to elucidate the functions of the large MAF transcription factor group in vivo, our research group created genetically modified MAFA-, MAFB-, and c-MAF-deficient mice and analyzed their phenotypes. MAFA is expressed in pancreatic β cells and is essential for insulin transcription and secretion. MAFB is essential for the development of pancreatic endocrine cells, formation of inner ears, podocyte function in the kidneys, and functional differentiation of macrophages. c-MAF is essential for lens formation and osteoblast differentiation. Furthermore, a single-base mutation in genes encoding the large MAF transcription factor group causes congenital renal disease, eye disease, bone disease, diabetes, and tumors in humans. This review describes the functions of large MAF transcription factors in vivo and their relationships with human diseases.
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spelling pubmed-83903102021-08-31 Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases Takahashi, Satoru Exp Anim Review The large MAF transcription factor group is a group of transcription factors with an acidic region, a basic region, and a leucine zipper region. Four types of MAF, MAFA, MAFB, c-MAF, and NRL, have been identified in humans and mice. In order to elucidate the functions of the large MAF transcription factor group in vivo, our research group created genetically modified MAFA-, MAFB-, and c-MAF-deficient mice and analyzed their phenotypes. MAFA is expressed in pancreatic β cells and is essential for insulin transcription and secretion. MAFB is essential for the development of pancreatic endocrine cells, formation of inner ears, podocyte function in the kidneys, and functional differentiation of macrophages. c-MAF is essential for lens formation and osteoblast differentiation. Furthermore, a single-base mutation in genes encoding the large MAF transcription factor group causes congenital renal disease, eye disease, bone disease, diabetes, and tumors in humans. This review describes the functions of large MAF transcription factors in vivo and their relationships with human diseases. Japanese Association for Laboratory Animal Science 2021-03-23 2021 /pmc/articles/PMC8390310/ /pubmed/33762508 http://dx.doi.org/10.1538/expanim.21-0027 Text en ©2021 Japanese Association for Laboratory Animal Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review
Takahashi, Satoru
Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases
title Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases
title_full Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases
title_fullStr Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases
title_full_unstemmed Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases
title_short Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases
title_sort functional analysis of large maf transcription factors and elucidation of their relationships with human diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390310/
https://www.ncbi.nlm.nih.gov/pubmed/33762508
http://dx.doi.org/10.1538/expanim.21-0027
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