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Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases
The large MAF transcription factor group is a group of transcription factors with an acidic region, a basic region, and a leucine zipper region. Four types of MAF, MAFA, MAFB, c-MAF, and NRL, have been identified in humans and mice. In order to elucidate the functions of the large MAF transcription...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Association for Laboratory Animal Science
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390310/ https://www.ncbi.nlm.nih.gov/pubmed/33762508 http://dx.doi.org/10.1538/expanim.21-0027 |
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author | Takahashi, Satoru |
author_facet | Takahashi, Satoru |
author_sort | Takahashi, Satoru |
collection | PubMed |
description | The large MAF transcription factor group is a group of transcription factors with an acidic region, a basic region, and a leucine zipper region. Four types of MAF, MAFA, MAFB, c-MAF, and NRL, have been identified in humans and mice. In order to elucidate the functions of the large MAF transcription factor group in vivo, our research group created genetically modified MAFA-, MAFB-, and c-MAF-deficient mice and analyzed their phenotypes. MAFA is expressed in pancreatic β cells and is essential for insulin transcription and secretion. MAFB is essential for the development of pancreatic endocrine cells, formation of inner ears, podocyte function in the kidneys, and functional differentiation of macrophages. c-MAF is essential for lens formation and osteoblast differentiation. Furthermore, a single-base mutation in genes encoding the large MAF transcription factor group causes congenital renal disease, eye disease, bone disease, diabetes, and tumors in humans. This review describes the functions of large MAF transcription factors in vivo and their relationships with human diseases. |
format | Online Article Text |
id | pubmed-8390310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83903102021-08-31 Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases Takahashi, Satoru Exp Anim Review The large MAF transcription factor group is a group of transcription factors with an acidic region, a basic region, and a leucine zipper region. Four types of MAF, MAFA, MAFB, c-MAF, and NRL, have been identified in humans and mice. In order to elucidate the functions of the large MAF transcription factor group in vivo, our research group created genetically modified MAFA-, MAFB-, and c-MAF-deficient mice and analyzed their phenotypes. MAFA is expressed in pancreatic β cells and is essential for insulin transcription and secretion. MAFB is essential for the development of pancreatic endocrine cells, formation of inner ears, podocyte function in the kidneys, and functional differentiation of macrophages. c-MAF is essential for lens formation and osteoblast differentiation. Furthermore, a single-base mutation in genes encoding the large MAF transcription factor group causes congenital renal disease, eye disease, bone disease, diabetes, and tumors in humans. This review describes the functions of large MAF transcription factors in vivo and their relationships with human diseases. Japanese Association for Laboratory Animal Science 2021-03-23 2021 /pmc/articles/PMC8390310/ /pubmed/33762508 http://dx.doi.org/10.1538/expanim.21-0027 Text en ©2021 Japanese Association for Laboratory Animal Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Review Takahashi, Satoru Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases |
title | Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases |
title_full | Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases |
title_fullStr | Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases |
title_full_unstemmed | Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases |
title_short | Functional analysis of large MAF transcription factors and elucidation of their relationships with human diseases |
title_sort | functional analysis of large maf transcription factors and elucidation of their relationships with human diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390310/ https://www.ncbi.nlm.nih.gov/pubmed/33762508 http://dx.doi.org/10.1538/expanim.21-0027 |
work_keys_str_mv | AT takahashisatoru functionalanalysisoflargemaftranscriptionfactorsandelucidationoftheirrelationshipswithhumandiseases |